应用多西紫杉醇治疗晚期乳腺癌的疗效分析

Efficacy Analysis of Docetaxel in the Treatment of Advanced Breast Cancer

目的探讨多西紫杉醇治疗晚期乳腺癌的临床疗效。方法回顾性分析我院收治的48例晚期乳腺癌患者的临床资料,根据治疗方法不同分为治疗组和对照组各24例,其中对照组患者采用希罗达治疗,治疗组患者在对照组的基础上加用多西紫杉醇治疗,比较两组患者的临床疗效和不良反应发生情况。结果治疗组患者的总有效率为79.17%,对照组患者的总有效率为58.33%,两组比较差异有统计学意义,P<0.05;治疗组患者治疗期间出现4例Ⅲ～Ⅳ胃肠道反应、4例Ⅲ～Ⅳ骨髓抑制、11例脱发、3例中性粒细胞减少、2例手足综合征,对照组患者出现5例Ⅲ～Ⅳ胃肠道反应、6例Ⅲ～Ⅳ骨髓抑制、15例脱发、4例中性粒细胞减少、4例手足综合征。结论多西紫杉醇治疗晚期乳腺癌患者,毒副作用相对较低,临床疗效显著。

Objective To explore the clinical effect of Docetaxel in the treatment of advanced breast cancer. Methods The clinical data of 48 patients with advanced breast cancer were analyzed retrospectively. All cases were divided into the treatment group and control group according to the therapy method. 24 cases in the control group received the Xeloda treatment, while 24 cases of the treatment group received the Docetaxel treatment on the basis of Xeloda treatment. The clinical effects and adverse reactions of two groups were compared. Results The total effect rate was 79.17%, and 58.33 % in the control group; the difference of total effective rate was statistically significan （P 〈0.05）. The treatment group had 4 cases of III - IV gastrointestinal reaction, 4 cases of III - IV myelosuppression, 11 cases of hair loss, 3 cases of decreased neutrophile granulocyte and 2 cases of hand-foot syndrome during the treatment period; while the control group had 5 cases of III - IV gastrointestinal reaction, 6 cases of Ill - IV myelosuppression, 15 cases of hair loss, 4 cases of decreased neutrophile granulocyte and 4 cases of hand-foot syndrome during the treatment period. Conclusions The application of Docetaxel in the treatment of advanced breast cancer has significant clinical effect, and lower toxic and side effect.