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急性冠脉综合症患者较大剂量他汀药物干预结果分析 被引量：1

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摘要 目的观察急性冠脉综合症(ACS)患者应用不同剂量阿托伐他汀治疗的效果。方法选取ACS患者90例,按给予阿托伐他汀剂量不同分为对照组和观察组,各45例,所有患者均给予硝酸酯类、血管紧张素转化酶抑制剂、-受体阻滞剂、阿斯匹林、波立维及低分子肝素等常规治疗。对照组在常规治疗基础上给予阿托伐他汀20 mg/d睡前口服;观察组在常规治疗基础上给予阿托伐他汀40 mg/d睡前口服;分别测定治疗前后的高敏C反应蛋白(hs-CRP)及血脂水平,并记录缺血性事件发生次数及不良反应发生率。结果对照组与观察组治疗后血脂差异无统计学意义(均>0.05);两组治疗后hs-CRP水平明显下降、缺血性事件发生率也明显减少,差异均有统计学意义(均<0.05)。结论较大剂量他汀药物早期干预能明显抑制ACS的炎症反应,降低血浆hs-CRP水平,减少缺血性事件的发生率。
作者 章慧炯 徐亚伟
机构地区 宁波市祥星医院 上海市第十人民医院
出处 《现代实用医学》 2013年第7期765-767,共3页 Modern Practical Medicine
关键词 急性冠脉综合症 他汀类药物 HS-CRP 缺血性事件
分类号 R543.3 [医药卫生—心血管疾病]
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参考文献7

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二级参考文献7

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现代实用医学
2013年 第7期

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