培养滤液蛋白10/靶6000蛋白检测对结核性脑、胸膜炎早期诊断的临床研究被引量：1

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摘要目的探讨靶6000蛋白(ESAT-6)和培养滤液蛋白10(CFP-10)在早期辅助诊断结核性脑、胸膜炎中的价值。方法将收集的29例阳性病例(结核性脑膜炎及胸膜炎的患者)和30例对照病例应用酶联免疫吸附法(ELISA)检测其脑脊液或胸水ESAT-6和CFP-10蛋白,并与用聚丙烯酰胺凝胶块浓缩脑脊液或胸水后检测ESAT-6和CFP-10蛋白浓度进行比较。结果浓缩前的标本:CFP-10的灵敏度为62.1%,特异度为86.7%;ESAT-6的灵敏度为68.9%,特异度为90%;两蛋白联合诊断的灵敏度为79.3%,特异度为96.7%。浓缩后的标本:CFP-10的灵敏度为68.9%,特异度为86.7%;ESAT-6的灵敏度为72.4%,特异度为90%;两蛋白联合诊断的灵敏度为89.6%,特异度为96.7%。浓缩前后病例组与对照组的CFP-10和ESAT-6蛋白的阳性率差异均有统计学意义(均<0.05)。结论 ESAT-6和CFP-10检测结核具有较高的灵敏度和特异度,且简便和廉价,适合用于早期辅助诊断。

作者陆芳陈慧敏

机构地区宁波大学医学院宁波市第二医院

出处《现代实用医学》 2013年第7期768-770,共3页 Modern Practical Medicine

关键词结核胸膜结核脑膜靶6000蛋白培养滤液蛋白10

分类号 R521.7 [医药卫生—内科学] R529.3 [医药卫生—内科学]

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