人感染H7N9型禽流感病毒机制研究进展

Pathogenesis of human infected H7N9 subtype virus：a brief review

最近在中国大陆发生了人类感染禽流感H7N9病毒事件，这提醒我们对低致病性禽流感要提高警惕。禽流感从禽类传播至人类仍是散发性的，但人类感染后的病死率非常高。迄今为止，还没有针对禽流感的预防性疫苗。该文旨在阐述H型、H7N9型禽流感的致病性、分析H7N9突破种间屏障感染人类的可能机制及其由低致病性禽流感病毒转变成高致病性禽流感病毒的分子发病机制。

The outbreak of avian influenza A virus subtype H7N9 in humans in China has aroused our attention to low pathogenic avian influenza（LPAI） viruses recently. Although the transmission of avian influenza from birds to humans has proved to be sporadic, the mortality of infected humans is very high. No specific vac- cine has been produced to prevent avian influenza which means that we still have a long way to cure and/or e- liminate the disease. We review the pathogenicity of H7 and H7N9 subtype viruses, the mechanisms of how H7N9 subtype virus infect humans and its molecular pathogenesis of transformation from low pathogenic avian influenza viruses to highly pathogenic avian influenza viruses,in order to understand the pathogenesis of H7N9 a- vian influenza viruses.