海水浸泡感染后皮肤软组织缺损修复的差异性观察Δ

Different observations of skin and soft tissue defect repair with seawater immersion after infection

[目的]观察海水浸泡感染后人工材料置入皮肤软组织缺损的修复研究。[方法]取狗左右桡骨中段截骨制成开放性皮肤软组织及骨缺损动物模型,随机分成二组,实验组海水浸泡伤口2 h,对照组开放伤口自然暴露2 h,感染后3 d分别给予伤口清创并置入人工骨,每组各12只,创面共24例,并以玻璃纤维石膏绷带固定,术后12周观察各组动物皮肤、软组织愈合及材料移动情况,并行统计学分析。[结果]a:术后12周实验组皮肤及软组织愈合差于对照组,P<0.05,有统计学意义;b:术后12周实验组与对照组材料移动情况无明显差别,P>0.05,无统计学意义。[结论]海水浸泡感染后动物皮肤及软组织愈合差于自然暴露感染动物,海水浸泡与自然暴露材料稳定性一样差。

[ Objective ] To research artificial materials for skin soft tissue defect repair with seawater immersion after infection. [Methods] We took osteotomies of the middle bilateral radius of a dog, which was an animal model used to study open skin soft tissue and bone defects. The animals were randomly divided into the following 2 groups ： 1 ） The experimental group （ wounds were treated with seawater immersion for 2 hours） ; 2） The control group （ open wounds were treated with natural expo- sure for 2 hours） . Three days after infection, the wounds were debrided and inserted into an artificial bone. Each group included 12 animals （24 wound cases） . The wounds were fixed with a glass fiber plaster bandage, and we observed the skin, soft tissue healing, and material movement of each animal 12 weeks after surgery. A chi - square test was used to compare groups. [ Results] Twelve weeks after surgery, the healing of skin and soft tissue was significantly poorer in the experimental group than in the control group （ U = 39. 50, P 〈 0. 05 ） . In regard to the material movement, there were no significant difference between the experimental and control groups. [ Conclusion ] Skin and soft tissue healing with seawater immersion after infection is poorer than natural exposure. The material stability in the seawater immersion group is as bad as that in the natural exposure group.