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靶向细胞周期G2调控点在恶性血液病治疗作用的研究进展

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摘要 细胞周期与恶性肿瘤的发生发展密切相关。肿瘤患者接受反复化疗后,体内有一部分肿瘤细胞通过细胞周期阻滞及自我防御修复机制持续存活,造成化疗耐药、肿瘤复发难治。以细胞周期调控尤其以G2期调控蛋白为靶向的化疗增敏研究成为当今热点。近年研究表明,G2期靶点抑制剂不仅在实体瘤的体内外治疗中起到重要作用,而且在多种恶性血液病中也显示出重要意义。笔者综述了G2期调控中一些重要靶点蛋白在实体瘤及恶性血液病的研究进展,以期为新治疗策略的提出提供思路。
出处 《国际输血及血液学杂志》 CAS 2013年第4期455-459,共5页 International Journal of Blood Transfusion and Hematology
基金 基金项目:国家自然科学基金(30870914,81270582),浙江省自然科学基金杰出青年项目(LR12H08001),浙江省卫生厅支撑学科重点项目(201234445,2012ZDA013),浙江省中医药局(2012ZA071)
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  • 1Mueller PR,Coleman TR,Dunphy WG. Cell cycle regulation ofa XenopusWeel-like kinase. Mol Biol Cell, 1995,6(1): 119-134.
  • 2Thornton BR, Toczyski DP. Securin and B-cycIin/CDK are theonly essentialtargets of the APC. Nat Cell Biol,2003,5(12):1090-1094.
  • 3Kellogg DR. Weel-dependent mechanisms required forcoordination of cell growth and cell division. J Cell Sci,2003,116(Pt 24): 4883-4890.
  • 4Magnussen Gl, Holm R,Emilsen E, et al. High expression ofWeel is associated with poor disease-free survival in malignantmelanoma: potential for targeted therapy. PLoS One, 2012. 7(6): e38254.
  • 5Murrow LM, Garimella SV, Jones TL,et al. Identification ofWEEl as a potential molecular target in cancer ceils by RNAiscreening of the human tyrosine kinome. Breast Cancer ResTreat, 2010, 122(2): 347-357.
  • 6Bridges KA. Hirai H, Buser CA,et al. MK-1775, a novel Weelkinase inhibitor, radiosensitizes p53-defective human tumorcells. Clin Cancer Res, 2011, 17(17) : 5638-5648.
  • 7Tominaga Y, Li C,Wang RH, et al. Murine Weel plays acritical role in cell cycle regulation and pre-implantation stages ofembryonic devel叩ment. Int J Biol Sci, 2006, 2(4) : 161-170.
  • 8Hashimoto O, Shinkawa M,Torimura T,et al. Cell cycleregulation by the Weel inhibitor PD0166285. pyrido [2,3-d]pyimidine, in the B16 mouse melanoma cell line. BMC Cancer,2006’ 6: 292.
  • 9Tibes R, Bogenberger JM, Chaudhuri L,et al. RNAi screeningof the kinome with cytarabine in leukemias. Blood, 2012,119(12): 2863-2872.
  • 10Lindsey-Boltz LA, Sancar A. Tethering DNA damagecheckpoint mediator proteins topoisomerase II beta-bindingprotein 1 (TopBPl) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related ( ATR )phosphorylation of checkpoint kinase 1 (Chkl). J Biol Chem,2011, 286(22): 19229-19236.
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