长期使用活性维生素D安全性的相关性研究

Study of the safety of long-term use of active vitamin D

目的对连续和间断服用活性维生素D治疗6个月的骨质疏松症者,测24 h尿钙定量比较,了解长期使用活性维生素D的安全性。方法采用美国GE公司生产的Luner Prodigy Advance型骨密度仪测定骨密度确定为骨质疏松者106例。56例患者连续服用活性维生素D6个月为治疗组,50例患者间断服用活性维生素D6个月为对照组。采用美国强生VIPRO 250仪器干化学法测定24 h尿钙定量。采用德国罗氏MODULAR PPISE 900仪器酶速率法测定血液生化指标。结果治疗组与对照组相比,差异无显著性(P>0.05)。结论肝肾功能正常的骨质疏松患者,生理剂量内活性维生素D连续服用6个月,对机体是安全的。

Objective To investigate the safety of long-term use of active vitamin D by detecting 24-hour urinary calcium in patients who received 6-month continuous or intermittent therapy of oral active vitamin D for the treatment of osteoporosis. Methods A total of 106 patients, who were diagnosed with osteoporosis by detecting bone mineral density using Luner Prodigy Advance bone absorptiometry （ GE Co. , USA） , were included in this study. Fifty-six patients in treatment group continuously took active vitamin D for 6 months, while 50 patients in control group intermittently took active vitamin D for 6 months. The quantitative 24-hour urinary calcium was detected using dry chemical method with VIPRO 250 devices （Johnson ＆ Johnson, USA）. The blood biochemical parameters were measured using enzyme velocity method with MODULAR PPISE 900 devices （Roche, Germany）. Results No significant difference between the 2 groups was observed （P 〉 0.05）. Conclusion For the osteoporosis patients with normal liver and renal function, it is safe to administer physiological doses of active vitamin D for 6 months.