成人侏儒症患者骨密度检测结果及分析

The test results and analysis of bone mineral density in adult dwarfism

目的检测成人侏儒症患者腰椎、右髋、左髋骨密度值,与正常同龄人体检组相比较,探讨成人侏儒症患者与骨质疏松的相关性。方法采用法国MEDI MINK公司生产的OSTEOCORE 3双能X线骨密度检测仪检测28例成人侏儒症患者腰椎、左髋、右髋骨密度,求出均值,以最低值作为诊断依据,并随机选出38例体检的正常同龄人与之比对。结果患病组与对照组两组相比,年龄无差异,P=0.13>0.005;身高有显著性差异,P=0.000<0.005;体重有显著性差异,P=0.000<0.005;腰椎骨密度均值有显著性差异,P=0.000<0.005;右髋骨密度均值有显著性差异,P=0.000<0.005;左髋骨密度均值有显著性差异,P=0.000<0.005。28例侏儒症患者中骨量正常0例,占0%、骨量减少4例,占14.29%、骨质疏松24例,占85.71%、其中骨质疏松中达严重骨质疏松者12例。结论成人侏儒症患者骨量减少合骨质疏松患病率达100%,无一例骨密度正常,要高度重视这一特殊人群的骨髂健康。

Objective To measure the bone mineral density of the lumbar vertebrae, the right iliac, and the left iliac in adult patients with dwarfism, comparing that with normal people of the same age, and to investigate the correlation between adult dwarfism and osteoporosis. Methods The bone mineral density of the lumbar vertebrae, the right iliae, and the left iliac were measured in 28 adult patients with dwarfism using Osteoeore 3 dual - energy X - ray absorptiometry （ MED MINK Co. , France）. The mean value was calculated and the lowest value was set as diagnosis criteria. Meanwhile, 38 normal people of the same age were randomly selected. The bone mineral density was also measured and compared. Results There was no significant difference of age between 2 groups （ P 〉 0. 05 ） , while both the height and the weight in two groups showed significant difference （P 〈 0. 005）. The bone mineral density of the lumbar vertebrae, the right iliac, and the left iliac between two groups showed significant difference （P 〈 0. 005）. Among 28 adult patients with dwarfism, none of them had normal bone mass. Four patients had reduced bone mass （ 14.29% ） , and 24 patients had osteoporosis （85.71%）. Twelve out of 24 patients had serious ostcoporosis. Conclusion The prevalence of reduced bone mass combined with osteoporosis in adult patients with dwarfism is 100%. None patient has normal bone mass. It is very important to focus on bone health in adult dwarfism.