苏木及其提取物对免疫的影响

Effect of hematoxylin and its extract on immune system

苏木是中药常用药,具有活血祛瘀、消肿定痛作用,亦常用于恶性肿瘤的治疗。研究表明,苏木可通过调节免疫机制发挥抗肿瘤作用,但随着病期进展苏木抑瘤、抗转移作用会逐渐减弱,相关机制尚不十分明确。近年来苏木作为免疫调节剂在临床应用及实验研究方面均取得了一定进展。文章试从其对胸腺的影响、对脾脏的影响以及对外周血免疫细胞及免疫分子的影响等几个方面对其实验研究作一简要综述,以进一步指导其在肿瘤免疫调节中作用机制的研究。

Hematoxylin is a kind of commonly used traditional Chinese medicine, and it has the effect of promoting blood circulation and removing blood stasis, and detumescence and relieving pain. It may play an anti-tumor effect by regulating the immune mechanism, but with the stage of disease progress hematoxylin antitumor and antimetastatic effects will gradually weaken, the relevant mechanism is not very clear. Some progress has been made in clinical application and experimental study for how hematoxylin effects on immune system as an immunomodulator in recent years. This article would review its effects on thymus, spleen and the peripheral blood immune cells and immune molecules to guide the future studies.