摘要
目的比较阿立哌唑和氯氮平治疗精神分裂症的疗效及安全性。方法将100例精神分裂症患者随即分成2组各50例,分别给予阿立哌唑和氯氮平治疗。于治疗前及治疗后第2、4、8周采用阳性与阴性症状量表、副反应量表评定临床疗效与不良反应。结果研究组治疗2、4、8周末,一般精神病理因子分于2周末较治疗前有极显著下降;阳性症状、阴性症状因子分治疗4周末均较治疗前有显著下降(P均<0.01)。研究组不良反应发生率较低,程度较轻。结论阿立哌唑治疗精神分裂症疗效与氯氮平相当,且安全性高,依从性好,值得临床推广应用。
Objective To compare the clinical effects and safety of aripiprazole and dozopine treating schizophrenia.Methods One hundred patients with schizophrenia were randomly divided into the aripipiprazole group and the dozapine group.All patients were evaluated with the Positive and Negative Syndrome Scale(PANSS) and the Treatment Emergent Symptom Scale(TESS) before treatment and after treatment at the second,forth and eighth weeks.Results After treatment at the second,forth and eighth weeks,the total score and general psychopathological factor score of the PANSS were significantly reduced compared with before treatment with aripiprazole(P0.01).At the forth and eighth weeks,the positive and negative factor scores of the PANSS were aslo significantly reduced compared with before treatment with aripiprazole(P0.01).The incidence of adverse effects of aripiprazole group were lower and lighter.Conclusion Aripiprazole has a similar efficacy with clozapine in the treatment of schizophrenia and it is a safe and effective antipsychotic drug.
出处
《中国实用神经疾病杂志》
2013年第13期39-41,共3页
Chinese Journal of Practical Nervous Diseases