将代谢组学技术用于阿尔茨海默病中医证候研究

Metabonomics Technology Used in Study of TCM Syndrome of Alzheimer's Disease

阿尔茨海默病是一种发病机制复杂的疑难疾病,中医对本病有一定的疗效,证候是中医认识疾病和辨证论治的主要依据,是人"受病已发"的反应状态,系统生物学中的代谢组学技术可全面的、动态的研究机体确实已经发生了的代谢事件,可用来描述"证"的生化状态,这种方法在高血压、糖尿病等的中医证候研究中已取得进展。目前对阿尔茨海默病中医证候微观特征的研究较少,故可采用代谢组学技术来阐释本病的中医证候,了解其证候的物质基础,为其临床治疗提供参考。

The pathogenesis of Alzheimer＇s disease is complicated. Traditional Chinese medicine have certain curative effect on it, and treatment based on syndrome differentiation is the basic principle of understanding and treating diseases in TCM. Metabonomics technology can comprehensively and dynamically reflect the metabolic events that indeed happened in the human body, so it can be used to describe the biochemical state of syndrome. This method has been used in expounding the syndrome of hypertension; diabetes, etc, also, it has made some progress.At present, research on microscopic characteristics of TCM syndrome of AD is few, therefore, metabonomics technology can be used to illustrate the TCM syndrome of AD, clarify the material basis of its syndrome, and then provide reference for its clinical treatment.