摘要
目的:观察七味白术散合痛泻要方加味治疗腹泻型肠易激综合征(D-IBS)的疗效。方法:67例D-IBS患者完全随机分为观察组(n=34)与对照组(n=33)。观察组给予七味白术散合痛泻要方加味治疗,1剂/d;对照组给予匹维溴铵50 mg,3次/d;两组疗程均为8周。比较两组治疗前与治疗2、4、8周后腹痛评分、腹泻评分、症状总评分及总有效率的差异。结果:与治疗前比较,两组腹痛、腹泻评分及症状总评分在治疗2、4、8周后均显著降低(P<0.01);治疗2周后,观察组的腹泻评分及症状总评分显著低于对照组(P<0.01);治疗4、8周后,观察组的腹痛、腹泻评分及症状总评分均显著低于对照组(P<0.01);治疗8周后,观察组的总有效率显著高于对照组(P<0.05),而两组不良反应发生率无显著性差异(P>0.05)。结论:七味白术散合痛泻要方加味治疗腹泻型肠易激综合征疗效显著,无明显不良反应。
Objective:To observe the therapeutic effect on diarhea-predominant irritable bowel syndrome ( D-IBS ) with Qiwei Baizhu Powder and Tongxie Yaofang. Methods : 67 patients with D-IBS were randomly divided into observing group ( n=34 ) and control group ( n=33 ). The former was treated with Qiwei Baizhu Powder and Tongxie Yaofang ( 1 dose per day ), and the latter with Pinaverium bromide ( 50 mg, three times a day ). Both groups were treated for 8 weeks, to compare the scores of abdominal pain, diarrhea and con-symptom before and after treated for 2,4 and 8 weeks in both groups, and to compare the total effective and side-effect rate of the two groups after 8 weeks' treatment. Results : The scores of abdominal pain, diarrhea and con-symptom were decreased significantly after treated for 2,4 and~ 8 weeks, compared to those before treatment in each group (P〈0.01). Compared to control group, the scores of diarrhea and con-symptom in observing group were decreased significantly after 2 weeks' treatment( P〈0.01 ). At the end of week 4 and 8, the scores of the three items in observing group were all significantly lower than those of control group (P〈0.01). After 8 weeks' treatment, the total effective rate in observing group was significantly higher than that of control group ( P〈0.05 ), with no significant difference in side-effect rate ( P〉0.05 ). Conclusion : The therapeutic effect on D-IBS with Qiwei Baizhu Powder and Tongxie Yao^ang was notable, without obvious side effect.
出处
《辽宁中医药大学学报》
CAS
2013年第8期187-189,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
肠易激综合征
腹泻
七味白术散
痛泻要方
疗效
irritable bowel syndrome
diarhea
Qiwei Baizhu Powder
Tongxie Yaofang
effect