摘要
目的 观察他汀类药物在心房颤动治疗中的作用.方法 将2008年1月至2011年1月阿拉善盟中心医院收治的86例持续性心房颤动患者完全随机分为他汀组和对照组,各43例.给予体外同步直流电复律后2组均给予胺碘酮200 mg、3次/d口服,1周后改为200 mg、2次/d,再1周后改为200 mg、1次/d维持；他汀组同时给予辛伐他汀20 mg,每晚1次口服.患者复律前后均给予华法林钠正规抗凝治疗,共治疗6个月.患者恢复窦性心律后1、2周及以后每4周分别行心电图和动态心电图检查.结果 他汀组维持窦性心律38例（88.4％）,未维持窦性心律5例（11.6％）；对照组维持窦性心律29例（67.4％）,未维持窦性心律14例（32.6％）.他汀组维持窦性心律的比例明显高于对照组（P＜0.05）.结论 他汀类药物在预防心房颤动复发上有应用价值.
Objective To detect the role of statin drugs in the treatment of atrial fibrillation.Methods Totally 86 cases with atrial fibrillation were collected between January 2008 and January 2011.The patients were randomly divided into two groups.After being given in vitro synchronous dc after cardioerter,both groups had amiodarone 200 mg （200 mg/piece） with 3 times a day,200 mg with 2 times a day after one week,and 200 mg once a day for a long term.Statin group also had simvastatin 20 mg （20 mg/piece） every night.All patients were given warfarin sodium fomal anticoagulant therapy before and after cardioerter.Total treatment was for 6 months.Results The statin group showed sinus rhythm in 38 cases （88.4%） ; the control group showed sinus rhythm in 29 cases （67.4%）.The proportion of sinus rhythm in simvastatin group was significantly higher than that in the control group （88.4% vs 67.4%,P〈0.05）.Conclusion Statins can prevent recurrence of atrial fibrillation.
出处
《中国医药》
2013年第8期1043-1044,共2页
China Medicine
