高尿酸血症与冠心病患者性别关系的研究

The relation between hyperuricemia and gender in patients of coronary heart disease

目的 探讨高尿酸血症与冠心病患者性别的关系.方法 选取2012年3-9月于安贞医院急诊综合病房住院患者75例.将40例冠心病患者按性别分为男性冠心病组和女性冠心病组,各20例；同期入组的对照组为经冠状动脉造影证实冠状动脉正常的疑似冠心病患者,男20例,女15例,回顾性收集入选受试者的资料,比较2组患者的年龄、血尿酸、空腹血糖、血肌酐、血脂的情况.结果 男、女冠心病组的平均血尿酸水平未达到高尿酸血症的标准[（351±67）μmol/L、（310 ±74） μmol/L],男性冠心病组尿酸水平高于女性冠心病组（P＜0.05）.男性冠心病组尿酸水平与男性对照组[（327±82）μmol/L]比较差异无统计学意义（P＞0.05）.女性冠心病组尿酸水平显著高于女性对照组[（216 ±52） μmol/L],差异有统计学意义（P＜0.01）.女性冠心病组的HDL-C[（1.09±0.19） mmol/L]低于女性对照组[（1.27±0.23） mmol/L]（P＜0.05）,而TG[（1.6±0.6）mmol/L]高于女性对照组[（1.1 ±0.4）mmol/L]（P＜0.05）.结论 高尿酸血症可能是女性冠心病患者的一个危险因素.

Objective To discuss the relations between hyperuricemia （HUA） and gender of patients with coronary heart disease （CHD）.Methods Seventy-five patients hospitalized in department of emergency during of Anzhen Hospital from March 2012 to September 2012 were selected.Forty patients were divided into male CHD group and female CHD group by gender,each group had 20 cases; there were twenty male controls and fifteen female controls were selected at the same time.The subjects＇ data were retrospectively collected,age,serum uric acid,fasting blood-glucose,serum creatinine,blood lipid of two groups were compared respectively.Results The average blood uric acid level of female-CHD,male-CHD groups has not reached the standard of HUA [（351 ± 67） μmol/L,（310 ±75）μmol/L],the serum uric acid levels of male-CHD group was higher than that of female-CHD group（P 〈 0.05）.There was significant difference on serum uric acid level of male-CHD group [（351 ±67）μmol/L] compared with that of male control group [（327 ± 82） μmol/L] （P 〉 0.05）.The serum uric acid level female-CHD group [（310 ±757）μmol/L] was significantly higher than that of female control group [（216 ±52）μmol/L] （P 〈 0.01）.The high-density cholesterol of female-CHD group [（1.09 ± 0.19） mmol/L] was lower than that of female control group [（1.27 ± 0.23） mmol/L] （P 〈 0.05）,but triglycerides of female-CHD group [（1.6 ± 0.6） mmol/L] was higher than that of female control group [（1.1 ± 0.4） mmol/L] （P 〈 0.05）.Conclusion HUA may be a risk factor for female patients with CHD.