米非司酮配伍米索前列醇终止早孕阴道出血量的相关因素研究

A Analysis of Related Factors of Volume of Vaginal Bleeding on Termination of Early Pregnancy Using Mifepristone in Combination with Misoprostol

目的探讨米非司酮配伍米索前列醇终止妊娠天数为35～90d者阴道出血的相关因素。方法采用SPSS18.0统计学软件,单因素分析采用χ2检验,多因素分析采用多因素非条件logistic回归分析。对该中心2009年12月—2013年1月自愿要求药物流产对象的阴道出血量与可能的影响因素进行描述和分析。结果该研究共961例对象实施了药物流产,出血量多者占43.2%。单因素分析结果显示:年龄为35～40岁者出血量多于17～34岁者;孕期为50～90d者多于35～49d者;有妊娠史和有分娩史者分别高于无妊娠史和无分娩史者;多因素非条件logistic回归分析结果表明:孕期为50～90d(OR=1.824,可信区间为1.294～2.571)、有妊娠史(OR=1.994,可信区间为1.408～2.825)和有分娩史(OR=1.335,可信区间为1.977～1.823)3个因素是出血量多的危险因素。结论米非司酮配伍米索前列醇终止早孕的阴道出血量与年龄、孕期、妊娠史、分娩史有关,且孕期为50～90d、有妊娠史和有分娩史为出血量多的危险因素。

Objective To analyze related factors of volume of vaginal bleeding on termination of early pregnancy between 35 to 90 days using Mifepristone in combination with Misoprostol. Methods To describe and analyze the information of women who desire early abortion with drugs voluntarily from December 2009 to January 2013 in our center. That information includes volume of vaginal bleeding and potential influencing factors. Statistical software SPSS 18.0 which contain X2 test to analyze single variable, non-logistic regression to analyze multiple variables were used for the data processing. Results There were 961 women who used Mifepristone in combination with Misoprostol to terminate early pregnancy. The ratio of large volume of bleeding was 43.2%. The single variable analysis results showed that the volume of bleeding of age between 35-40 years was more than that of age between 17-34 years （P〈0.05）. The volume of bleeding in groups of gestational age between 50-90 days was more than that of gestational age between 35-49 days （P〈0.05）. The volume of bleeding of women who had pregnancy history were more than those not, so do the women who had delivery experience （P〈0.05）. The non-logistic analysis results showed that gestational age between 50-90 days （OR=1.824, 95% CI is 1.294-2.571）, pregnancy experience（OR=1.994, 95%CI is 1.408-2.825） and delivery experience （OR= 1.335, 95%CI is 0.977-1.823） were the risk factors of large volume of bleeding. Conclusion The volume of vaginal bleeding of using Mifepristone in combination with Misoprostol to terminate early pregnancy is related to age, gestational age, pregnancy histo- ry and delivery history. Gestational age between 50-90 days, pregnancy experience and having delivery history are risk factors of more volume of bleeding.