探讨肺炎克雷伯菌临床感染的护理方式及对β-lactams药物耐药性的主决定因素

Explore Klebsiella pneumoniae clinical infection care and main determinants of β-lactam's drug resistance

目的:研究探讨肺炎克雷伯菌(本文以下使用英文简称"KNP")临床感染的护理方式及对药物耐药性的主决定因素。方法:2011年1月～2013年1月,于我院共选择110例患者作为研究对象。首先对患者实施积极的护理干预,以防止院内感染。之后对患者送检物实施β-lactams的活性测定以及细胞膜的通透性测定。结果:和敏感菌株比较,泛耐药菌株以及多重耐药的菌株β-内酰胺酶(本文以下使用英文简称"β-lactamase")的活性显著增多,差异具有统计学意义(P<0.05)。泛耐药菌株以及多重耐药的菌株两者的外膜的通透性相对于敏感菌株而言,具有显著的阻碍作用,差异具有统计学意义(P<0.05)。结论:合理护理,可有效防止医院院内感染。且β-lactamase的活性以及细胞外膜的通透性是KNP对β-lactams耐药性的主决定性因素,对抗生素药物的筛选具有一定的指导意义。

Objective：To study and explore Klebsiella pneumoniae （we use the following abbreviation ＂KNP＂）clinical infection care and main determinants of β-lactams’s drug resistance.Methods：From January 2011 to January 2013,a total of 110 patients in our hospital for the study.The first to implement the proactive patient care intervention in order to prevent nosocomial infections.After got the patients’examination of the specimens,measuring the activity of beta-lactams and the determination of the permeability of the cell membrane.Results：comparison with sensitive strains.Pan-resistant strains and multi-resistant strains of beta-lactamase（we use the following abbreviation ＂β-lactamase＂）activity were significantly increased.The difference was statistically significant （P0.05）.Pan-resistant strains,and multi-resistant strains of both the outer membrane permeability with respect to sensitive strains,with a significant impediment.The difference was statistically significant （P0.05）.Conclusion：Reasonable did by the implementation of care,which can effectively prevent nosocomial infections.And the enzyme activity of beta-lactam and the permeability of the outer cell membrane were the main decisive factors KNP for the resistance of the beta-lactams.Antibiotic drug screening had certain guiding significance.