速效救心丸对非ST段抬高型急性冠脉综合征患者超敏C反应蛋白及基质金属蛋白酶-9的影响

Influence of Suxiao Jiuxin Pill on the Level of High-sensitivity C-reactive Protein and Matrix Metalloproteinase-9 on Patients with non-ST Elevation Acute Coronary Syndrome

目的观察速效救心丸对非ST段抬高型急性冠脉综合征(NSTACS)患者超敏C反应蛋白(hs-CRP)及基质金属蛋白酶-9(MMP-9)的影响。方法入选NSTACS患者63例,将其随机分为常规治疗组和速效救心丸治疗组。常规治疗组采用常规治疗,速效救心丸治疗组在常规治疗的基础上加服速效救心丸,入院后6h内及4周后检测两组患者hs-CRP及MMP-9水平的变化情况。结果两组患者入院后6h内血hs-CRP及MMP-9水平比较,差异无统计学意义(P>0.05);4周后速效救心丸治疗组血hs-CRP及MMP-9水平低于常规治疗组,差异有统计学意义(P<0.05)。结论速效救心丸能够降低NSTACS患者血hs-CRP及MMP-9水平,提示该药具有稳定斑块及抗动脉硬化的作用。

Objective To observe the influence of Suxiao jiuxin pill on the level of high-sensitivity C-reactive protein（hs-CRP） and matrix metalloproteinase-9（MMP-9） in patients with Non-ST elevation acute coronary syndrome（NSTACS）.Methods 63 selected cases with NSTACS were randomly divided into Suxiao jiuxin pill treatment group and normal treatment group.The normal treatment group received routine therapy,Suxiao jiuxin pill treatment group based on routine treatment plus service Suxiao jiuxin pill treatment,the levels of hs-CRP and MMP-9 among subjects in two groups were detected in 6 hours and after 4 weeks after admission.Results The hs-CRP and MMP-9 levels in the two groups were conpared after admission 6h,there were no significant difference（P ＆gt; 0.05）;After 4 weeks available Suxiao jiuxin pill treatment group blood hs-CRP and MMP-9 levels were lower than the normal treatment group,the difference was statistically significant（P ＆lt; 0.05）.Conclusion Suxiao jiuxin pill could reduce the blood hs-CRP and MMP-9 levels of patients with NSTACS suggesting that the drug has stable plaque and anti-atherosclerosis effect.