维吾尔族人群血尿酸水平与非酒精性脂肪性肝病的关系研究

Relationship between Serum Uric Acid Level and Non-alcoholic Fatty Liver Disease in Uygur

目的探讨维吾尔族人群非酒精性脂肪性肝病(NAFLD)的患病率以及血尿酸水平与NAFLD的关系。方法对2011年7月—2012年7月在新疆医科大学第一附属医院进行体检的2 241例维吾尔族受检者进行问卷调查,测量体质指数、腹围、血压、空腹血糖(FPG)、血脂、血尿酸等。结果 NAFLD和高尿酸血症的检出率分别为43.90%(984/2 241)和8.38%(188/2 241)。NADLD患者的血尿酸水平〔(320±88)μmol/L〕高于非NAFLD者〔(254±80)μmol/L〕,差异有统计学意义(P<0.05);高尿酸血症患者的NAFLD发生率(78.19%)高于非高尿酸血症人群(40.83%),差异有统计学意义(P<0.05)。除FPG升高外,代谢综合征、血压升高、高三酰甘油血症、低高密度脂蛋白胆固醇血症、中心性肥胖的发生率均随着SUA水平的增加而增加(P<0.05)。多元Logistic回归分析显示,高尿酸血症对NAFLD的影响有统计学意义〔OR=2.086,95%CI(1.344,3.237)〕。结论在维吾尔族人群中血尿酸水平与NAFLD密切相关,血尿酸水平增加是NAFLD的危险因素。

Objective To investigate the prevalence of non-alcoholic fatty liver disease（NAFLD） and the relationship between serum uric acid（SUA） level and NAFLD in Uygur.Methods We conducted a questionnaire survey among 2 241 Uygurs（1 214 males and 1 027 females） who had physical checkups in the First Affiliated Hospital of Xinjiang Medical University between July 2011 and July 2012.Body mass index（BMI）,abdominal circumference,blood pressure,fasting plasma glucose,fasting plasma glucose,and SUA level were measured.Results The prevalence rates of NAFLD and hyperuricemia were 43.90%（984 /2 241） and 8.38%（188 /2 241）,respectively.NAFLD patients had significantly higher SUA level than those without NAFLD 〔（320 ± 88） μmol / L vs.（254 ± 80） μmol / L,P〈 0.05〕.The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than in those without（78.19% vs.40.83%,P〈 0.05）.The increase of SUA level was associated with increased fasting plasma glucose,and higher prevalence of metabolic syndrome,blood pressure elevation,hypertriglyceridemia,low high-density lipoprotein cholesterol,and central obesity（P〈 0.05）.Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD 〔odds ratio = 2.086,95% confidence interval（1.344,3.237） 〕.Conclusion SUA level is significantly associated with NAFLD,and elevated SUA level is an independent risk factor for NAFLD in Uygur ethnic group of China.