新疆各民族慢性化脓性中耳炎病原菌及耐药性分析

Analysis of Pathogenic Bacteria and Its Drugresistance in Chronic Suppurative Otitis Media in Xinjiang Uygur Autonomous Region

目的研究新疆地区各民族慢性化脓性中耳炎主要致病菌的种类及耐药情况。方法对自2008年1月-2012年6月376例住院的慢性化脓性中耳炎患者中耳腔分泌物进行细菌培养及药敏分析。结果 376例患者共分离出384株病原菌,其中金黄色葡萄球菌149株(38.8%)居首位,其次是铜绿假单胞菌89株(23.1%)、表皮葡萄球菌60株(15.8%)、变形杆菌39株(10.2%)、真菌18(4.7%)、其他菌株29(7.5%)。金黄色葡萄球菌对青霉素的耐药性最高,而对莫西沙星等有较高的敏感性。铜绿假单胞菌对庆大霉素、哌拉西林/他唑巴坦、丁胺卡那霉素等有较高的敏感性。结论金黄色葡萄球菌和铜绿假单胞菌是新疆地区的慢性化脓性中耳炎主要致病菌,各民族间无明显差异。

Objective To study the pathogenic bacteria and its resistance to antibiotics in chronic suppurative otitis media in Xinjiang Uygur Autonomous Region. Methods Secretion from 376 cases with chronic suppurative otitis media was cultured. Drug sensitivity tests were done to separate pathogenic bacteria. Results 384 strains pathogenic bacteria were isolated from middle ear secretion. The main pathogenic bacteria were staphylococcus aureus （ 149 strains ） , pseudomonas aeruginosa（ 89 strains） , staphylo- coccus epidermidis（60 strains）, proteus （39 strains） and fungus （18 strains）. Staphylococcus aureus was sensitive to penicillin. Conclusion Staphylococcus aureus and pseudomonas aeruginosa were main pathogens of chronic suppurative otitis media in Xinjiang Uygur Autonomous Region, while there was no significant difference between several nationalities. Levofloxacin will be a good Experience medicine. Doctors should choose the sensitive antibiotics for treatment of the chronic suppurative otitis media.