良性前列腺增生与心脑血管疾病关系探讨

Relationship between Benign Prostatic Hyperplasia and Cardiovascular and Cerebrovascular Disease

目的探讨良性前列腺增生(BPH)与颈动脉粥样硬化、高血压、脑梗塞等心脑血管疾病的关系。方法选择141例老年BPH患者,所有患者均经超声检查前列腺体积(PV)及颈动脉颅外段,分为PV≤50 ml组和PV>50 ml组,比较两组颈动脉内中膜厚度(IMT)的平均值和最高值。结果 PV≤50 ml组103例,PV>50 ml组38例,颈总动脉(CCA)IMT的最高值,差异有统计学意义(P<0.05),而颈动脉IMT的平均值两组间差异无统计学意义(P>0.05)。高血压、脑梗塞、IMT的最高值与BPH独立相关(P<0.05)。结论颈动脉粥样硬化、高血压、脑梗塞与BPH独立相关,PV明显增大的患者需要更关注心脑血管疾病的控制。

Objective To explore the relationship between benign prostatic hyperplasia（BPH） and carotid artery disease, hypertension and cerebral infarction. Methods 141 elderly BPH patients with 103 prostatic volume（PV） ≤50 ml and 38 PV 〉 50 ml were selected. All patients＇ PV and extracranial carotid artery were calculated by colour Doppler ultrasound examination. Re- suits The maximum of intimal medial thickness of carotid artery in PV 〉 50 ml group was significantly higher than PV ~ 50 ml group（ P 〈0.05 ）. Multivariable analysis showed that therosclerosis ,hypertension and cerebral infarction were independent factors associated with BPH respectively （ P 〈 0. 05 ）. Conclusion Carotid therosclerosis, hypertension and cerebral infarction were associated with BPH.