不孕症患者血清免疫性抗体检测的临床价值与治疗体会

Clinical Value of Immune Serum Antibody Detection and Treatment of Patients with Infertility

目的探讨血清免疫性抗体与不孕症的关系,为临床诊疗提供参考与思路。方法于2006年1月-2012年10月,对300例不孕症患者进行血清免疫学检查,并与同期常规孕前查体的300例健康人群进行对比。对不孕症患者进行治疗,并在治疗3个月后与3个月前进行对比分析。结果不孕组的AsAb、EMAb、AoAb、AzpAb阳性率均显著高于对照组(P<0.05),不孕组以上两组阳性、三组阳性、四组阳性患者均显著高于对照组(P<0.05)。不孕症组患者治疗后3个月后的AsAb、EMAb、AoAb、AzpAb阳性率均显著低于治疗前(P<0.05)。治疗后自然受孕率显著提高,辅助受孕率显著提高(P<0.05)。结论血清免疫性抗体异常是不孕症的一个重要原因,进行正规治疗对免疫性不孕抗体转阴具有一定价值。

Objective To investigate the relationship between serum autoimmune antibodies and infertility, to provide a reference for the clinical diagnosis and treatment. Methods From January 2006 to October 2012,300 cases of infertility patients were given immunological studies, during the same period,300 cases of healthy people were compared. After 3 month of treatment for infertility patients, treatment were compared with 3 months ago. Results AsAb, EMAb, AoAb and AzpAb positive rate of infertile group were significantly higher than those in the control group（P 〈 0.05 ）. Two sets of positive, three sets of positive, four positive patients of the infertility group were significantly higher than those in the control group（ P 〈 0.05 ）. After the treatment of infertil- ity patients after 3 month, AsAb, EMAb, AoAb and AzpAb positive rate were significantly lower than before treatment（P 〈 0.05 ）. After treatment, the rate of natural conception and the assisted conception rate significantly increased （ P 〈 0.05 ）. Conclusion Serum antibody immune abnormalities was an important cause of infertility, formal treatment of immune infertility had a certain value for antibody negative.