腔内热疗或深部热疗联合同期放化疗治疗中晚期宫颈癌的疗效分析

THE EFFICACY OF CAVITY MICROWAVE HYPERTHERMIA/DEEP HYPERTHERMIA COMBINED WITH CONCURRENT RADIOCHEMOTHERAPY IN THE TREATMENT OF LOCALLY ADVANCED CERVICAL CANCER

目的探讨宫颈癌治疗方法中热疗配合同期放化疗的最佳模式及毒副反应。方法将在我院收治的初诊宫颈癌90例患者(Ⅱa～Ⅲb期)随机分为三组进行治疗。A组:单纯同期放化疗;B组:同期放化疗+腔内微波热疗;C组:同期放化疗+深部射频热疗。每组各30例患者,观察三组的近期疗效和毒副反应。结果热疗+同期放化疗组(B、C组)的肿瘤消退、完全缓解率均明显高于单纯同期放化疗组(A组),而毒副反应又低于A组。B、C组之间的疗效无明显差异,而在毒副反应上,B组的皮肤反应、直肠反应明显低于A、C组。结论热疗配合同期放化疗能提高肿瘤的控制率,而腔内热疗配合放化疗在宫颈癌的治疗中更具有重要意义,值得推荐。

Objective To investigate the best treatment modes and the lowest toxicity reaction of hyperthermia combined with concurrent radiochemotherapy in cervical cancer. Methods Ninety cervical cancer patents of stage II a to III b in author＇s hospital from February 2010 to April 2012 were randomly divided into three groups： group A was treated by concurrent radiochemotherapy, group B was treated with cavity mi- crowave hyperthermia plus radiochemotherapy, group C was treated with deep hyperthermia plus radioche- motherapy. The short term efficacy and toxicity of three groups were observed. Results In experimental group（B, C）, the complete response rates and local control rates were significantly higher than the control group（A）, and whose early toxicity was less than the control group. The curative effect about the two groups（B, C） had no obvious differences. But the skin reaction and rectal reaction were obviously lower in group B than those in groups（A, C）. Conclusion Hyperthermia combined with concurrent radiochemotherapy can improve the tumor control, and the cavity microwave hyperthermia plus radiochemotherapy in treatment of cervical cancer has more important significance, be worth to recommend.