摘要
目的探讨多模式MRI指导的颈内动脉系统急性期脑梗死患者接受重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓后发生出血转化的相关危险因素。方法对103例急性期颈内动脉系统脑梗死患者在标准时间窗(4.5h内)进行rt-PA静脉溶栓治疗。观察患者性别、年龄、吸烟、饮酒、高血压病、糖尿病、房颤、血脂、NIHSS评分及ASPECT评分与溶栓后出血的相关性。结果溶栓后发生出血转化的患者共17例,其中症状性脑出血患者有5例,占所有溶栓患者的4.85%、所有出血患者的29.41%。溶栓后脑出血与房颤、NIHSS评分及ASPECT评分均有相关性(P<0.05)。结论有房颤、NIHSS评分高及ASPECT评分低者行rt-PA静脉溶栓容易发生出血转化。
Objective To identify risk factors for intracerebral hemorrhage following Multi-modality MRI-based intravenous thrombolytic therapy with rt-PA for acute cerebral infarction in carotid territory.Methods 103 patients with acute carotid territory stroke received intravenous rt-PA within 4.5 hours of symptom onset.The factors including gender,age,smoking,alcohol,hypertension,diabetes mellitus,atrial fibrillation,blood lipids as well as NIHSS and ASPECT scores were collected to correlated with risks of intracerebral hemorrhage.Results After intravenous rt-PA administration,17 patients combined with intracerebral hemorrhage,5 patients developed symptomatic intracerebral hemorrhage account for 4.85% of overall rt-PA treated patients and 29.41% of patients with intracerebral hemorrhage respectively.Risk of recurrence of intracerebral hemorrhage was closely correlated with atrial fibrillation and scores of NHISS and ASPECT.Conclusion Overall,rt-PA treated patients with atrial fibrillation,high scores of NHISS and low scores of ASPECT had an increased risk of intracerebral hemorrhage.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第7期619-621,共3页
Journal of Apoplexy and Nervous Diseases
基金
浦东新区卫生系统重点学科建设基金(PWZXK2010-03)
浦东新区卫生系统领先人才培养基金(PWR12010-02)
上海市浦东新区卫生局项目及科技发展基金创新项目(PKJ2011-Y28
PW2011B-7)
上海市浦东新区人民医院重点学科群项目
关键词
脑梗死
颈内动脉系统
静脉溶栓
脑出血
危险因素
Cerebral infarction
Carotid territory
Intravenous thrombolytic
Intracerebral hemorrhage
Risk factors