硒催化的噁唑啉-2-酮的合成

Synthesis 2-Oxazolidones with Selenium as Catalyst

研究了以硒粉作催化剂,一氧化碳为羰基化试剂的乙醇胺的羰基化反应,考察了氧化剂对反应的影响,没有氧化剂存在时,几乎没有羰基化反应的发生,还考察了不同的碱和不同的溶剂以及溶剂用量对反应的影响.在硒/氧气/一氧化碳体系存在下,乙醇胺分子内羰基化形成较为稳定的五元环产物——噁唑啉-2-酮,产率和选择性较高,对反应机理进行了讨论和解释.传统的合成噁唑啉-2-酮类物质的方法大都采用光气作羰基化试剂,光气的高毒性和苛刻的操作条件有很多的不便,而硒的催化合成方法具有环境友好性和原子经济性,是未来化学工业的重要发展方向。

The carbonlation of ethanolamine with selenium as catalyst in the presence of carbon monoxide was studied. The influence of some oxidants on the carbonylation was examined. Oxygen was found to be the best oxidant and almost no reaction was observed without adding any oxidant, and also studied different base, different solvents under the CO/O2 conditions have different infulences in the reaction, it was found that the carbonlation ethanolamine which have two neighbouring nuclepphilic groups in molecule tends to from intramolecular carbonylated products with fairly high yields and selectivity in the presence of some appropriate oxidante possible reaction pathwayas were postulated and discussed. The phosgene is usually used as carbonlyating agent in the typical synthesis 2 -oxazolidones, but it involves inconvenient critical processing conditions due to its high toxicity. Selenium catalytic process featuring environmental kindnessand atom economical selectivity,it was a key technology for further development of chemical industry in the future.