血脂代谢异常与子痫前期发病类型的关系

Relationship between blood lipid metabolic disorder and different types of preeclampsia

目的:通过比较子痫前期不同发病类型患者血脂指标的变化,探讨血脂代谢异常与不同发病类型子痫前期的发生发展的关系。方法:选取2010年1月～2012年12月在中国医科大学附属盛京医院规律产检,并首次诊断为子痫前期的孕妇130例,同时选择130例健康孕妇作为对照组,分析比较两组患者血脂相关指标。结果:重度子痫前期患者无论早发型或晚发型与正常妊娠者相比,甘油三酯、总胆固醇、低密度脂蛋白胆固醇、脂蛋白(a)均明显升高(P<0.01),其中早发型重度子痫前期脂蛋白(a)升高的更为显著(P<0.05)。结论:血脂代谢异常与重度子痫前期无论是早发型或是晚发型的发生发展均有一定的关系,早发型重度子痫前期与晚发型重度子痫前期可能存在不同的发病机制。

Objective： To explore the different actions of blood lipid metabolic disorder in development of different types of pre- eclampsia by investigating the changes of lipid metabolism in different types of preeclampsia. Methods： One hundred and thirty women with severe preeclampsia were enroUed in the study who had regular antenatal care in Shengjing Hospital of China Medical University from January 2010 to December 2012, and 130 normal pregnant women were taken as the matched control group, their relative data of blood lipid were compared. Results： Serum concentrations of triglyceride （TG）, total cholesterol （TCHO） , low density lipoprotein cholesterol （LDL-C） and lipoprotein （a） in severe preeclampsia group were significantly higher than those in control group （P 〈 0. O1 ）, and the changes in early onset severe preeclampsia were more significant （P 〈 0. 01 ） . And the lipoprotein （a） in early onset severe preeclampsia was significantly higher than that of late onset severe preeclampsia （P 〈 0. 05） . Conclusion： The changes of blood lipid metabolism may play a role in the development of severe preeclampsia. There may be different pathogenesis in early onset and late onset severe preeclampsia.