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CD44V6和MMP-2在乳腺癌中的表达及临床意义 被引量：4

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摘要 目的:探讨CD44V6和MMP-2基因蛋白在乳腺癌中的表达及作用。方法;在22例乳腺良性组织和58例乳腺癌中应用流式细胞术定量检测CD44V6和MMP-2的表达。结果:CD44V6和MMP-2在乳腺癌中的表达均明显高于乳腺良性组织(P<0.05),二者均与乳腺癌淋巴转移及临床分期密切相关(P<0.05),且在乳腺癌中CD44V6和MMP-2的表达呈正相关。结论:CD44V6和MMP-2的高表达促进了乳腺癌的侵袭和转移,提示CD44V6和MMP-2可作为乳腺癌诊断和预后判断的指标。
作者 朱慧芳 果永宽 史志春
机构地区 廊坊卫生职业学院
出处 《中国妇幼保健》 CAS 北大核心 2013年第23期3833-3834,共2页 Maternal and Child Health Care of China
基金 廊坊市2010年科学技术研究与发展指令性计划〔2010117101-5〕
关键词 乳腺癌 CD44V6 MMP-2 侵袭和转移 流式细胞术
分类号 R737.9 [医药卫生—肿瘤]
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共引文献30

同被引文献46

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中国妇幼保健
2013年 第23期

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