我国抗菌药物约定日剂量设定方法分析

Analysis of the Methods for Antibacterial DDD Assignment in China

目的:分析我国约定日剂量的设定方法。方法:通过收集中国知网和万方数据知识服务平台的相关资料,对2010年1月-2012年11月国内发表的文献中有关抗菌药物约定日剂量的设定方法进行列表比较。结果:我国抗菌药物约定日剂量设定方法多达49种,设定依据和设定值不尽相同。主要设定依据为《新编药物学》、药品说明书和《中华人民共和国药典临床用药须知》。设定值之间或与卫生部抗菌药物临床应用监测中心发布的约定日剂量相比,均存在不同程度的差异。结论:我国约定日剂量设定方法极不规范,应引起足够重视。

OBJECTIVE：To analyze the methods of DDD assignment in China.METHODS：By collecting related data from CNKI and Wanfang database,the methods of antibacterial DDD assignment in Chinese papers published from Jan.2010 to Nov.2012 were compared.RESULTS：There were 49 methods of antibacterial DDD assignment,and the assignment references and antibacterial DDD values were not all the same.The main references were New Pharmacology,package inserts and Clinical Guidance of Chinese Pharmacopoeia.There were many differences between antibacterial DDD assignment values and the values from MOH center for antibacterial surveillance.CONCLUSIONS：The methods of antibacterial DDD assignment are extremely not standard in China,which should be taken seriously.