南京地区33家医院2009-2011年抗真菌药利用分析

Analysis of the Utilization of Antifungal Agents in 33 Hospitals of Nanjing Area from 2009 to 2011

目的:了解南京地区医院抗真菌药的利用情况及趋势。方法:采用销售金额和用药频度(DDDs)分析及排序法,对南京地区33家医院2009-2011年抗真菌药的利用情况进行统计、分析。结果:该地区医院抗真菌药销售金额占抗菌药物总销售金额的比例呈逐年上升趋势。三唑类深部抗真菌药的销售金额构成比最大,年均增长率达14.66%,其中棘白霉素类药年均增长率最大(18.67%)。抗真菌药以进口品种为主,DDDs排序靠前的为三唑类药氟康唑和伊曲康唑,以及浅部抗真菌药特比萘芬。结论:该地区医院抗真菌药销售金额呈增长趋势,三唑类增长较为明显,提示临床应防范其耐药性的发生。

OBJECTIVE：To analyze the utilization and development trend of antifungal drugs in Nanjing area.METHODS：The utilization of antifungal drugs in 33 hospitals from Nanjing area during 2009-2011 was analyzed statistically in terms of consumption sum,DDDs and ranking.RESULTS：The proportion of consumption sum of antifungal agents in total consumption sum of antimicrobial agents increased year by year.The proportion of consumption sum of triazole was the highest with annual growth rate of 14.66%,among which maximum annual growth rate of echinocandina was up to 18.67%.The referred antifungal agents were mainly imported.Triazole antifungal agent fluconazole and itraconazole,terbinafine which belonged to the superficial antifungal agent took the lead in terms of DDDs.CONCLUSIONS：The consumption sum of antifungal agents,especially the triazole,appears increasing trend in Nanjing area,which alerts clinicians to prevent the occurrence of drug resistance.