1037例使用抗癫痫药患者的血药浓度监测结果分析

Analysis of Blood Concentration Monitoring of Antiepileptic Drugs in 1 037 Patients

目的:促进药物监测的受重视程度,为安全、合理使用抗癫痫药提供参考。方法:采用回顾性调查方法,收集我院2009年1月-2012年6月使用抗癫痫药(卡马西平、丙戊酸钠、苯妥英钠及苯巴比妥)的病例信息及血药浓度,利用SPSS20.0统计软件进行分析。结果:共收集使用上述4种抗癫痫药患者1037例,血药浓度在有效范围内的患者508例(48.99%),血药浓度低于有效范围的患者454例(43.78%),血药浓度高于有效范围的患者75例(7.23%)。除丙戊酸钠和苯巴比妥血药浓度在有效范围内的患者比例没有明显差异(P=0.98)外,其余药物之间血药浓度在有效范围内的患者比例均有明显差异(P<0.0071);使用卡马西平和丙戊酸钠的未成年群体血药浓度不同于成年群体(P<0.05)。结论:重视药物监测,尤其侧重于老年人及儿童群体,对保证安全、有效地使用抗癫痫药具有重要意义。

OBJECTIVE：To emphasize the drug monitoring and provide reference for safer and more reasonable use of antiepileptic drugs.METHODS：The information and blood concentration of epileptic patients receiving antiepileptic drugs therapy （carbamazepine,sodium valproate,phenobarbital） in our hospital were investigated retrospectively from Jan.2009-Jun.2012,and analyzed statistically by SPSS 20.0 software.RESULTS：1 037 epileptic patients who took 4 antiepileptic drugs were collected.The number of patients whose blood concentration were within therapeutic range,lower or higher ranges were 508 （48.99%）,454 （43.78%）,75 （7.23%）,respectively;the proportion of patients whose blood concentration were within therapeutic range among 4 drugs was different （P＆lt;0.007 1） except the sodium valproate and phenytoin （P=0.98）.In addition,the blood concentration of carbamazepine and sodium valproate in underage was different from that in adults （P＆lt;0.05）.CONCLUSIONS：It is of significance for safe and effective use of antiepileptic drugs that emphasize concentration monitoring,especially for the aged and children.