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肺癌患者体重、血糖浓度和病灶大小对^18F—FDGPET/CT病灶SUV的影响 被引量:3

The effect of lung cancer patients' weight, blood glucose concentration and lesion size of lung cancer on ^18F-FDG PET/CT lesions SUV results
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摘要 目的研究肺癌患者体重、血糖浓度和病灶大小对^18F—FDGPET/CT病灶SUV的影响。方法50例无糖尿病病史的肺癌患者中,21例有纵隔转移灶。所有患者均行常规^18F—FDGPET/CT,使用AdvantageWorkstation图像处理工作站自动提取肺癌病灶SUV以及经过体重和体型校正的SUV。采用半自动方法提取肝脏参考本底SUV。肺癌原发灶和转移灶诊断参考标准按照肝脏参考本底SUV或体型校正SUVx1.5+2×标准差。结果50例肺癌患者血糖浓度与肝脏参考本底SUV之间呈正相关,与肺癌原发灶SUV呈负相关,但是与转移灶SUV之间却呈正相关。按照参考诊断标准,50个肺癌原发灶和21个肺癌转移灶经过血糖浓度、病灶大小进行校正前和校正后,临床诊断的准确率分别为90.00%、71.43%和100%、95.24%。结论患者体重、血糖浓度和病灶大小对肺癌临床诊断准确率具有显著影响。经过血糖浓度、病灶大小校正后临床对肺癌诊断的准确率明显提高。这些结果提示,行^18F-FDGPET/CT诊断肺癌时,需要高度重视患者体重、血糖浓度和病灶大小对结果的影响。 Objective To study the effects of lung cancer patients' weight, blood glucose concentration and lesion size of lung cancer on ^18F-FDG PET/CT lesions SUV results. Methods Fifty cases of lung cancer patients without a history of diabetes mellitus were enrolled in this study. Among them, 21 patients with mediastinal metastases were detected. According to clinical routine ^18F-FDG PET/CT scanning, automatic extraction of lung cancer SUV, weight and size correction SUV were obtained using the GE Advantage Workstation image processing workstation. Liver reference background SUV was obtained using semi-automatic extraction method of extraction. Lung cancer primary tumors and metastatic lesions diagnosis reference standards were accordant with the liver reference background SUV or SUV shape correctionx1.5+2x standard deviation. Results Fifty cases of lung cancer in patients with blood sugar concentration and liver reference background SUV had positive correlation with lung cancer, SUV of primary lung cancer was negatively correlated with blood sugar, but it showed a positive correlation between blood sugar and lung metastases. According to the reference criteria for the diagnosis of 50 primary lung cancer cases and 21 metastatic lung cancer cases before and after the clinical diagnosis, the glucose concentration, lesion size correction accuracies were 90.00%, 71.43% and 100%, 95.24% respectively. Conclusions Patients' body weight, blood glucose concentration and lesion size significantly affect the accuracy of clinical diagnosis of lung cancer. After correction accuracy, it remarkably improved the clinical diagnosis of lung cancer. The results suggest that when using ISF-FDG PET/CT for lung cancer diagnosis, the effects of body weight, blood glucose concentration and lesion size should be concerned.
出处 《国际放射医学核医学杂志》 2013年第4期211-215,共5页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 肺肿瘤 氟脱氧葡萄糖F18 正电子发射断层显像术 体层摄影术 X线计算机 标准化摄取值 Lung neoplasms Fluorodeoxyglucose F18 Positron-emission tomography Tomography,X-ray computed Standardized uptake value
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