骨髓增殖性肿瘤与缺血性卒中

Myeloproliferative Neoplasms and Ischemic Stroke

骨髓增殖性肿瘤常出现血管并发症,最常累及脑血管,以缺血性卒中最为常见。骨髓增殖性肿瘤作为缺血性卒中的病因之一,其诊断与治疗不同于其他病因所致卒中。白细胞增多、JAK2V617F基因突变等相继被发现与缺血性卒中相关。本文对骨髓增殖性肿瘤伴缺血性卒中的发生、机制及防治的新进展进行综述。

Myeloproliferative neoplasms （MPNs） often occur with vascular complications, most commonly involving cerebrovascular, and ischemic stroke is the most common. MPNs as a cause of ischemic stroke are different to other causes of stroke in diagnosis and treatment. And leukocytosis and JAK2V617F mutations have been found associated with ischemic stroke. In this paper, an updated overview of morbidity and pathogenesis, prevention and treatment in MPNs with ischemic stroke is presented.