以抑郁症状为首发的阿尔茨海默病分析探究

Analysis of Alzheimer's Disease with First - episod Depressive Symptoms

目的：分析以抑郁症状为首发的阿尔茨海默病临床特征。方法：选择我院从2011年1月～2012年1月收治的阿尔茨海默病患者72例，其中36例以抑郁症状为首发的患者作为研究组，另外36例不以抑郁症状为首发的患者作为对照组，对于2组患者的各项情况以及精神症状进行对比分析。结果：研究组的抑郁症状、病前心理因素要明显高于对照组，研究组的人格改变、行为障碍发生率要明显低于对照组，差异均有统计学意义（P〈0．05）。结论：阿尔茨海默病患者的被动和退缩行为人格和情感症状常于痴呆病程的早期出现，同时伴有心理社会因素的患者会具有较为严重的抑郁情况，该类以抑郁症状为首发的阿尔茨海默病患者在进行诊断的过程中极易出现被误诊的情况，所以对于该类患者进行长期随访具有重要意义，可以使患者早期就得到有效治疗，使得病情发展得到延缓，同时也可极大提高患者日常生活质量。

Objective： To analyze the clinical features of Alzheimer＇s disease symptoms of depression for the first. Methods： in our hospital from 2011 January to 2012 January, 72 cases of hospitalized patients with Alzheimer＇s disease, in which 36 patients with de- pressive symptoms as initial as study group, another 36 cases without depressive symptoms for first - episode patients as control group, were analyzed for the two groups of patients and psychiatric symptoms. Results ： the disease symptoms of depression, the study group of psychological factors, morbidity was higher than that of control group, the study group personality change, behavior disorder rate was significantly lower than that of the control group, the difference was statistically significant （ P 〈 0.05 ）. Conclusion ： passive and with- drawal behavior personality and affective symptoms in patients with Alzheimer＇s disease often appear in early duration of dementia, with social and psychological factors have more severe depressive symptoms, such as depression symptoms as the first symptom in patients with Alzheimer＇s disease in the process of diagnosis is prone to be misdiagnosed, so for this kind of patients with long - term follow - up, which is important, can make patients early treatment, the progression of the disease slowed down, but also can greatly improve the quality of life in patients