利培酮联合舍曲林治疗精神分裂症阴性症状临床研究

Combination of Risperidone and Sertraline in Negative Symptoms of Schizophrenia

目的:探讨利培酮联合舍曲林治疗精神分裂症阴性症状的临床疗效和安全性。方法:将60例精神分裂症患者随机分为治疗组(利培酮+舍曲林)和对照组(利培酮)各30例,利培酮治疗剂量2~6mg/d,舍曲林50mg^200mg/d,疗程8周,治疗后采用阴性症状量表和副反应量表[1]评定临床疗效与不良反应。结果:2组治疗后阴性症状量表总分和因子分均显著下降,差异有统计学意义(P<0.05),治疗组阴性症状量表总分、情感平淡、思维贫乏、意志缺乏、兴趣缺乏等因子分较对照组下降明显,差异有统计学意义(P<0.05)。不良反应2组无显著性差异(P>0.05)。结论:利培酮联合舍曲林治疗精神分裂症阴性症状疗效优于单用利培酮治疗。

Objective：To explore the efficacies and safety of combination of risperidone and sertraline in negative symptoms of schizo- phrenia. Methods：60 schizophrenics were randomly divided into treatment （n = 30, took risperidone combined with sertraline） and control group （n =30,took risperidone ） dose of risperidone was 2 ~6mg/d and that of sertraline 100 ~200mg/d for 8 weeks. Before and after treatment , efficacies and side effects were assessed using the Negative Syndrome Scale（NSS） and the Treatment Emergent Symptom Scale （TESS）. Results ： After treatment total score and factors, score of the NSS of both 2 groups obviously reduced and differences were signifi- cant （ P 〈 0.05 ）. compared with the control group the total score of the NSS and factors＇, score of apathy poverty of thought abulia and in- terest blank obviously reduced in the treatment group and differences were significant （ P 〈 0.05 ）. there was no difference in side effects between the 2 groups. Conclusion：combination of risperidone and sertraline is better than single risperidone in the treatment of negative symptoms of schizophrenia.