Survivin和PTEN在非小细胞肺癌中的表达及临床意义

The expression and clinical significance of Survivin and PTEN in non small-cell lung cancer

目的探讨Survivin和PTEN在非小细胞肺癌(NSCLC)中的表达及临床意义。方法应用免疫组织化学EnVision法检测80例NSCLC组织和30例癌旁肺组织中Survivin及PTEN的表达,并分析其与临床病理因素之间的关系。结果肺癌组织中,Survivin和PTEN的阳性表达率分别为72.5%和33.8%,癌旁组织中Survivin和PTEN的阳性表达率分别为0和83.3%,Survivin随着肿瘤恶性程度增高,阳性表达率逐渐升高,而PTEN的表达则相反,二者在肿瘤中的表述呈负相关(r=-0.235,P<0.01)。结论 Survivin和PTEN的异常表达与NSCLC的发生发展有关,可作为判断肺癌生物学行为和预后的参考指标。

Objective To study the expression of Survivin and PTEN in non-small-cell lung cancer （NSCLC） and its clinical significane. Methods Survivin and PTEN expression were detected by immuno-histochemical technique （EnVision） in 80 cases of NSCLC tissues and 30 cases of corresponding adjacent tissues. The results were analyzed with clinicopathological parameters. Results The positive rates of Survivin and PTEN in NSCLC were 72.5% and 33.8%, 0 and 83.3% in corresponding adjacent tissues respectively. There were significant differences between NSCLC group and corresponding adjacent tissues group （P 〈 0.05）. The expression of Survivin increased gradually as increasing of malignancy.The expression of PTEN appeared in a reverse way. Their expression had negative correlation between each other（r= -0.235 ,P 〈 0.01 ）. Conclusion The abnormal expression of Survivin and PTEN gene play significant role in the occurrence and progression of NSCLC and can be identified as definite prognostic and reflecting biological behavior marker.