细胞因子信号转导抑制蛋白1与多发性骨髓瘤免疫治疗的研究进展

Research Advances in Suppressor of Cytokine Signaling-1 and Immune Therapy of Multiple Myeloma

细胞因子信号转导抑制蛋白1(SOCS1)是一种由细胞产生并反馈性抑制细胞因子信号转导的负性调节因子。SOCS1可抑制多种细胞因子的信号转导过程,如IL-6、IL-2、IL-12、IL-15、IL-7和干扰素等,也可通过抑制酪氨酸激酶-信号转导和转录激活因子(JAK-STAT)信号通路而抑制信号转导过程。同时SOCS1还可能通过影响T细胞的分化、成熟及活性和影响树突细胞的成熟及功能而参与免疫调控过程。通过基因干扰技术沉默树突细胞中的SOCS1可增强机体的抗肿瘤反应,这为一些恶性肿瘤(如多发性骨髓瘤)更有效的免疫治疗打下基础。

Suppressor of cytokine signaling-1（SOCS1） is produced in cells and identified as a classic negative feedback loop to regulate cytokine signal transduction.SOCS1 may inhibit cytokine signal transduction of some cytokines such as IL-6,IL-12,IL-15,IL-7,interferon and so on.At the same time,it could also inhibit JAK-STAT signal pathway.SOCS1 may also participate in some immune responses by regulating the differentiation,maturation and activation of T cells as well as the maturation and function of DC cells.It has recently been shown that silenced SOCS1 in DC by genetic interfering technology could enhance the effect of anti-tumor immunity,leading to more effective cancer immune therapy,which may be a basic knowledge for the immune therapy of multiple myeloma.