人参皂苷CK辅助治疗原发性肝癌的临床观察

Clinical Observation of Adjuvant Therapy of Ginsenoside CK on Primary Hepatocellular Carcinoma

目的观察人参皂苷CK辅助肝动脉化疗栓塞术(TACE)治疗原发性肝癌的临床疗效和安全性。方法采用随机双盲法将50例原发性肝癌患者分为人参皂苷CK组和对照组,各25例。观察两组患者治疗前后实体瘤近期疗效、患者生存质量、免疫功能变化、肝功能变化以及安全性指标。结果两组近期总有效率比较差异有统计学意义(P<0.05);人参皂苷CK组治疗后体力状况评分(KPS)评分升高稳定率较对照组显著增高(P<0.05);对照组治疗后CD3+、CD4+、CD4+/CD8+比值及自然杀伤细胞(NKC)均有一定程度的降低,而人参皂苷CK组相应指标均有不同程度的回升(P<0.05);两组治疗后Child-Pugh分级均有不同程度的改变,与人参皂苷CK组相比,对照组A级数量显著减少,B、C级数量显著增多(P<0.05);与人参皂苷CK组相比,对照组TACE后丙氨酸转氯酶(ALT)水平显著升高(P<0.05);与对照组相比,人参皂苷CK组TACE后不良反应的发生率显著降低(P<0.01)。结论人参皂苷CK可提高TACE的有效率,提高患者的生存质量,改善患者的免疫系统功能,减少TACE对患者免疫功能的损伤及肝损伤,并可降低TACE介入化疗药物的不良反应,用于辅助介入化疗治疗安全有效。

Objective To observe the clinical efficacy and safety of adjuvant therapy of ginsenoside CK on primary hepatocellular carcinoma after transcatheter arterial chemoembolization（TACE）.Methods Fifty patients who suffered from primary hepatocellular carcinoma were divided into ginsenoside CK group and control group by a randomized double blind method,25 patients per group.The immediate efficacy,quality of life,immune function changes,liver function changes and safety index of the two groups were observed both before and after treatment.Results The total immediate efficacy of the two group was significantly different（P 0.05）;the increasing and stability rate of Karnofsky scores of ginsenoside CK group was significantly increased than control group after treatment（P 0.05）;the levels of CD3＋,CD4＋,CD4＋/ CD8＋and natural killer cells（NKC） of control group decreased after treatment while the corresponding indicators of ginsenoside CK group had recovery of varying degrees（P 0.05）;the Child-Pugh classification of both group were varied changed after treatment,the numbers of A level of control group were obviously reduced compared with ginsenoside CK group,however the numbers of B and C levels were obviously increased compared with ginsenoside CK group（P 0.05）;the ALT level of control group was significantly increased compared with ginsenoside CK group after TACE（P 0.05）;the adverse reaction rate of ginsenoside CK group significantly decreased compared with control group after TACE（P 0.01）.Conclusion Ginsenoside CK can improve the effective rate of TACE,improve the survival quality and the immune-macrophage function of patients and reduce the immune-macrophage injury,liver injury,toxic and side effects afterTACE,which is safe and effective for auxiliary intervention chemotherapy.