期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

17S U2 snRNP中不可或缺的剪接因子SF3a的研究进展 被引量：1

Research Progress of Indispensable Splice Factor SF3a in 17S U2 snRNP
下载PDF
导出
摘要 剪接体由snRNPs(small nuclear ribonucleoprotein particles)和非snRNPs蛋白质组成,能通过剪接作用对内含子进行精确切除,形成成熟有活性的mRNA。SF3a是哺乳动物U2型主要剪接体中不可或缺的成分,参与形成有活性的17S U2 snRNP,由SF3a60、SF3a66、SF3a120构成。SF3a120与SF3a60和SF3a66互作,但SF3a60与SF3a66并不互作。文中对17U2 snRNP中的剪接因子SF3a的研究进展进行了阐述,证明了SF3a对于细胞的形态、分化、正常的生长发育具有重要作用。 Spliceosome is composed of snRNPs（small nuclear ribonucleoprotein particles） and non-snRNPs proteins.Spliceosome can excise introns precisely by splicing,forming mature active mRNA.SF3a complex is an important ingredient that forms active 17S U2 snRNP.SF3a is made up of SF3a60,SF3a66 and SF3a120,SF3a120 interacts with SF3a60 and SF3a66,while SF3a60 doesn’t interact with SF3a66.The research progress of SF3a of 17S U2 snRNP were elaborated,it was verified that SF3a plays an important role in cell morphology,differentiation,and its normal growth.
作者 林婵婵
机构地区 浙江师范大学化学与生命科学学院
出处 《安徽农业科学》 CAS 2013年第15期6604-6607,6676,共5页 Journal of Anhui Agricultural Sciences
基金 国家自然科学基金(31171519)
关键词 RNA剪接 剪接因子 SF3a PRE-MRNA RNA spicing Splicing factor SF3a pre-mRNA
分类号 S188 [农业科学—农业基础科学]
  • 相关文献

参考文献57

  • 1袁丽华,罗小洋,张吉翔.剪接因子——SF3b[J].生命的化学,2009,29(5):746-749. 被引量：3
  • 2CHANG T H,CLARK M W,LUSTIG A G,et al.RNA11 protein is associ-ated with the yeast spliceosome and is localized in the periphery of the cellnucleus[J].Molecular and Cellular Biology,1988,8(6):2379-2393.
  • 3ABOVICH N,LEGRAIN P,ROSBASH M.The yeast PRP6 gene encodes aU4/U6 small nuclear ribonucleoprotein particle(snRNP)protein,and thePRP9 gene encodes a protein required for U2 snRNP binding[J].Molecu-lar and Cellular Biology,1990,10(12):6417-6425.
  • 4ARENAS J E,ABELSON J N.The Saccharomyces cerevisiae PRP21 geneproduct is an integral component of the prespliceosome[J].Proceedings ofthe National Academy of Sciences,1993,90(14):6771-6775.
  • 5LEGRAIN P,CHAPON C.Interaction between PRP11 and SPP91 yeastsplicing factors and characterization of a PRP9-PRP11-SPP91 complex[J].Science,1993,262(5130):108-110.
  • 6BROSI R,GRNING K,BEHRENS S E,et al.Interaction of mammaliansplicing factor SF3a with U2 snRNP and relation of its 60-kD subunit toyeast PRP9[J].Science,1993,262(5130):102-105.
  • 7CHIARA M D,CHAMPION-ARNAUD P,BUVOLI M,et al.Specific pro-tein-protein interactions between the essential mammalian spliceosome-as-sociated proteins SAP 61 and SAP 114[J].Proceedings of the National A-cademy of Sciences,1994,91(14):6403-6407.
  • 8KRAMER A,LEGRAIN P,MULHAUSER F,et al.Splicing factor SF3a60is the mammalian homologue of PRP9 of S.cerevisiae:the conserved zincfinger-like motif is functionally exchangeable in vivo[J].Nucleic AcidsResearch,1994,22(24):5223-5228.
  • 9BROSI R,HAURI H P,KRAMER A.Separation of splicing factor SF3 intotwo components and purification of SF3a activity[J].Journal of BiologicalChemistry,1993,268(23):17640-17646.
  • 10KRAMER A,FERFOGLIA F,HUANG C J,et al.Structure-function analy-sis of the U2 snRNP-associated splicing factor SF3a[J].Biochemical So-ciety Transactions,2005,33(3):439.

二级参考文献16

  • 1Hastings ML et al. Pre-mRNA splicing in the new millennium. Curr Opin Cell Biol, 2001, 13(3): 302-309.
  • 2Tarn WY et al. Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge. Trends Biochem Sci, 1997, 22(4): 132-137.
  • 3Golas MM et al. Molecular architecture of the multiprotein splicing factor SF3b. Science, 2003, 300(5621): 980-984.
  • 4Wang Q et al. Interactions of the yeast SF3b splicing factor. Mol Cell Biol, 2005 , 25(24): 10745-10754.
  • 5Brosi R et al. Separation of splicing factor SF3 into two components and purification of SF3a activity. J Biol Chem, 1993, 268(23): 17640-17646.
  • 6Das BK et al. Characterization of a protein complex containing spliceosomal proteins SAPs49, 130, 145, and 155. Mol Cell Biol, 1999, 19(10): 6796-6802.
  • 7Will CL et al. A novel U2 and Ull/U12 snRNP protein that associates with the pre-mRNA branch site. EMBO J, 2001, 20 (16): 4536-4546.
  • 8Spadaccini R et al. Biochemical and NMR analyses of an SF3bI55-pI4-U2AF-RNA interaction network involved in branch point definition during pre-mRNA splicing. RNA, 2006, 12(3): 410-425.
  • 9Wang Q et al. Rds3p is required for stable U2snRNP recruitment to the splicing apparatus. Mol Cell Biol, 2003, 23(20): 7339- 7349.
  • 10Hashizume C et al. Human immunodeficiency virus type 1 Vpr interacts with spliceosomal protein SAP145 to mediate cellular pre-mRNA splicing inhibition. Microbes Infect, 2007, 9(4): 490-497.

共引文献2

同被引文献16

  • 1曾纪晴,张明永.选择性剪接在植物逆境相关基因表达调控中的作用[J].植物生理学通讯,2006,42(6):1005-1014. 被引量：8
  • 2HASTINGS ML,KRAINER AR.Pre-mRNA splicing in thenew millennium[J].Current Opinion in Cell Biology,2001,13(3):302-309.
  • 3BROSI R,HAURI HP,et al.Separation of splicing factor SF3into two components and purification of SF3aactivity[J].Journalof Biological Chemistry,1993,268(23):17 640-17 646.
  • 4CHEAH M T,WACHTER A,et al.Control of alternativeRNA splicing and gene expression by eukaryotic riboswitches[J].Nature,2007,447(7 143):497-500.
  • 5CARNINCI P,et al.(194coauthors).The transcriptionallandscape of the mammalian genome[J].Science,2005,309(5 740):1 559-1 563.
  • 6MODREK B,LEE C.A genomic view of alternative splicing[J].Nature genetics,2002,30(1):13-19.
  • 7KAZAN K.Alternative splicing and proteome diversity inplants:the tip of the iceberg has just emerged[J].Trends inplant science,2003,8(10):468-471.
  • 8BRYANT H E,WADD S E,et al.Herpes simplex virus IE63(ICP27)protein interacts with spliceosome-associated protein145and inhibits splicing prior to the first catalytic step[J].Journal of Virology,2001,75(9):4 376-4 385.
  • 9DAS B K,XIA L,et al.Characterization of a protein complexcontaining spliceosomal proteins SAPs 49,130,145,and 155[J].Molecular and Cellular Biology,1999,19(10):6 796-6 802.
  • 10HASHIZUME C,KURAMITSU M,et al.Human immuno-deficiency virus type 1Vpr interacts with spliceosomal proteinSAP145to mediate cellular pre-mRNA splicing inhibition[J].Microbes and Infection,2007,9(4):490-497.

引证文献1

二级引证文献3

安徽农业科学
2013年 第15期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部