儿童特发性血小板减少性紫癜患者血清β_2微球蛋白及血小板活性变化研究

Study on the change of serum β_2-microglobulin and platelet activity of children with idiopathic thrombocytopenic purpura

目的探讨儿童特发性血小板减少性紫癜患者血清β2微球蛋白及血小板活性的变化情况。方法选取2011年2月—2012年4月于本院进行治疗的39例特发性血小板减少性紫癜患儿为观察组,同期进行健康体检的39名健康儿童为对照组,然后将两组儿童的血清β2微球蛋白及血小板活性指标进行比较,并将观察组中不同分级及初发复发患儿的上述指标进行比较。结果观察组的血清β2微球蛋白及血小板活性指标均明显高于对照组,同时观察组中3级患儿的上述指标水平高于1级和2级患儿,2级患儿则高于1级患儿,P均<0.05,均有显著性差异,而初发与复发患儿之间无明显差异,P均>0.05。结论儿童特发性血小板减少性紫癜患者血清β2微球蛋白及血小板活性呈现升高的趋势,且不同分级患儿之间也有明显的差异。

Objective To study the change situation of serum β2-microglobulin and platelet activity of children with idiopathic thrombocytopenic purpura. Methods 39 children with idiopathic thrombocytopenic purpura in our hospital from February 2011 to April 2012 were selected as observation group, and 39 healthy children with health examinationat the same time were selected as control group, then the serum β2-microglobulin and platelet activity indexes of two groups were compared, then these indexes of observation group with different grades and primary or relapse were compared. Results The serum β2-microglobulin and platelet activity indexes of observation group were obviously higher than those of control group, and these inde of observation group with grade 3 were all higher than those with grade 1 and grade 2, these of observation group with grade 2 were all higher than those with grade 1, all P 〈 0.05, there were all significant differences, while these indexes of observation group with primary and relapse had no obvious differences, all P〉0.05. Conclusion The serum β2-microglobulin and platelet activity of children with idiopathic thrombocytopenic purpura shows an increasing trend, and these indexes of children with different grades have obvious differences.