热疗联合化疗在晚期消化道肿瘤中的临床应用

Clinical application of hyperthermia combined with chemotherapy in advanced gastrointestinal cancer

目的了解热疗联合化疗治疗晚期消化道肿瘤的疗效和安全性。方法选择2010年1月—2013年1月消化道肿瘤患者50例,并随机分为两组,分别为参照组和治疗组,每组各25例。参照组根据病情采用相应方案进行单一全身化疗;治疗组采用化疗和热疗(HG_2000体外高频热疗)联合治疗,每组治疗时间为14d以上,并对治疗效果和安全性进行评价。结果 50例消化道肿瘤患者均获得一定的治疗效果,其中治疗组的效果高于参照组,具有统计学差异(P<0.05);相对于治疗组来说,参照组消化道反应和骨髓抑制毒副作用较高,差异具有统计学意义(P<0.05)。结论相对于单一治疗来说,热疗联合化疗在治疗晚期消化道肿瘤方面具治疗效果好、毒副作用小等优势,可以进行大范围推广和应用。

Objective To understand the curative effect and safety of hyperthermia combined with chemotherapy in the treatment of advanced gastrointestinal cancer. Methods Select 50 cases of gastrointestinal cancer in January 2010 - January 2013, and randomly divided into two groups, the reference group and treatment group, each group of 25 people. The reference group were treated with single systemic chemotherapy according to the condition; treatment group were treated with chemotherapy and thermotherapy （extracorporeal high-frequency hyperthermia with HG_2000）, treatment time for each group was more than 14 days, and to evaluate the therapeutic effect and safety. Results 50 cases of patients with digestive tract cancer showed a certain therapeutic effect, the effect of treatment group was higher than the reference group, with statistical difference （P 〈 0.05） ; Compared to the treatment group, reference group of gastrointestinal reaction and inhibition of bone marrow toxicity is higher, with statistical significance （P 〈 0.05）. Conclusion Compared with the single therapy, hyperthermia combined with chemotherapy has a therapeutic effect on the treatment of advanced gastrointestinal tumors, less toxic side effect and other advantages, can be large-scale promoted and applied.