摘要
目的制备头孢地尼-聚乙烯吡咯烷酮(PVP-K30)固体分散体,提高头孢地尼的溶出度。方法利用溶剂法制备头孢地尼-PVP-K30固体分散体,利用紫外分光光度计法进行溶出度测定,利用差热分析(DSC)和红外光谱仪(FTIR)、扫描电镜(SEM)分析固体分散体中头孢地尼分散状态。结果利用溶剂法成功制备头孢地尼-PVP-K30固体分散体。与头孢地尼原药及物理混合物相比,头孢地尼-PVP-K30固体分散体中头孢地尼溶出度明显增加,且溶出度随着载体质量比例增加而增大。DSC、FTIR与SEM结果表明,头孢地尼与载体PVP-K30以无定形存在于固体分散体中。结论以PVP-K30为载体制备头孢地尼-PVP-K30固体分散体可有效改善头孢地尼溶出性能。
Objective To prepare the cefdinir-PVP-K30 solid dispersion （SD） for improving the dissolution rate of eefdinir. Methods Cefdinir-PVP SD was prepared by solvent method. The dissolution rate in vitro was determined by UV spectrophotometer. Differential scanning calorimetry （DSC）, fourier transform infrared spectroscopy （FFIR） and scanning electron micrograph （SEM） were used to analyze the characteristics of cefdinir and PVP-K30 in SD. Results The SD was prepared successfully. Compared with the dissolution rate of cefdinir and its physical mixture （ PM）, the dissolution rate of SD was significantly higher and increased with the carrier content. According to DSC,FFIR and SEM, cefdinir and PVP-K30 existed amorphously in the SD. Conclusion The technique can be used for increasing the dissolution rate of cefdinir.
出处
《医药导报》
CAS
北大核心
2013年第8期1072-1075,共4页
Herald of Medicine
