甘氨双唑钠与顺铂在老年Ⅱ/Ⅲ期食管癌放疗中的增敏作用及不良反应

Comparison of sensitization of CMNa and DDP in the radiotherapy in elderly Ⅱ/Ⅲ esophageal carcinoma and its adverse reactions

目的比较甘氨双唑钠(CMNa)与顺铂(DDP)在老年食管癌放射治疗(RT)中的增敏作用和不良反应。方法 60例老年食管癌首程放疗患者被随机分为CMNa+RT、DDP+RT两组。均采用6MV的直线加速器进行常规分割放疗。用药方法:CMNa+RT组:CMNa 800mg/m2放疗前1h静脉滴注,每周1、3、5用药,至放疗(照射剂量:60～64Gy)结束。DDP+RT组:DDP 25mg/m2加入生理盐水250ml静脉滴注,每周1次至放疗结束。结果 CMNa+RT组和DDP+RT组的完全缓解率相近,差异无统计学意义(P>0.05)。CMNa组的不良反应发生率明显低于DDP组,差异有统计学意义(P<0.05)。结论 CMNa和DDP对食管癌均具有放疗增敏作用,两者无明显差异,而CMNa较顺铂不良反应小。

Objective To compare radiosensitivity enhancement between DDP（Cisplatin） and CMNa（Sodium Glycididazole） in patients with esophageal carcinoma.Methods 60 patients with esophageal carcinoma were randomly divided into two groups.There were 30 cases in CMNa＋RT group,administrated with CMNa 800 mg/㎡,every Monday,Wednseday,and Friday.The regimen was repeaated till the end of the radiotherapy（DT：60-64Gy）.There were 30 cases in DDP TRT group,administrated with DDP 25mg/m2,every week.The regimen was repeated till the end of the radiotherapy.Results CMNa and DDP could enhance the radiosensitivity to advanced esophageal carcinoma.The radiosensitivity enhancement of two groups were similar（P0.05）.The radiation complication in the groups of CMNa＋RT regimen was more tolerable than DDP＋RT regimen（P0.05）.Conclusion There is no singnificant difference in radiosensitivity in two groups,but CMNa＋RT regimen was more tolerable than DDP＋RT regimen.