丙泊酚复合瑞芬太尼在脑动脉狭窄支架置入术中的应用

Effect Analysis of Propofol Combined With Remifentanil Anesthesia in Patients With Cerebral Artery Stenosis Stenting

目的探讨丙泊酚复合瑞芬太尼在脑动脉狭窄支架置入术的临床疗效。方法将2011年5月～2012年5月间在我院治疗并择期进行脑动脉狭窄支架置入术的40例患者,随机分成观察组和对照组,每组20例。两组患者麻醉诱导相同,对照组吸入异氟醚、静脉注射丙泊酚维持麻醉;观察组以注射泵输注丙泊酚和瑞芬太尼维持麻醉。比较两组患者围手术期的心率HR、收缩压SBP、舒张压DBP、自主呼吸恢复时间、苏醒时间、定向力回复时间及血糖、皮质醇的变化。结果观察组插管前后血压、心率无明显变化(P>0.05);对照组患者血压升高,心率加快(P<0.05)。对照组在插管后,血糖、皮质醇显著增高(P<0.05);观察组则无显著性变化(P>0.05)。结论丙泊酚复合瑞芬太尼麻醉维持手术中应激反应小,血液动力学稳定,是一种安全有效的麻醉方法。

Objective To explore the effect of propofol combined with remifentanil anesthesia in patients with Cerebral artery stenosis stenting.Methods Collected 40 cases conducted with Cerebral artery stenosis stenting from May 2011 to May 2012 in our hospital,who were randomly divided into trial group and control group,each group was 20 cases.The anesthesia induction was same in the two groups.In the control group,inhaled isoflurane,intravenously injected Propofol maintain anesthesia;in the observation group,given propofol combined with remifentanil anesthesia.Compared heart rate（HR）,systolic blood pressure and diastolic blood pressure,spontaneous breathing recovery time,palinesthesia time,orientation force recovery time and changes about blood sugar,cortisol of patients during perioperative period.Results The blood pressure and heart rate did not change in the observation group before and after intubation（P0.05）;elevated blood pressure and faster heart rate were found in the control group after tracheal intubation（P0.05）.The bblood sugar and cortisol increased in the control group after intubation（P0.05）.The observation group had no significant change（P0.05）.Conclusion Propofol combined with remifentanil anesthesia has smallstress reaction,stable hemodynamics,which is a safe and effective anesthesia method.