阿托伐他汀钙对脑梗死患者血脂、超敏C-反应蛋白和动脉粥样硬化的影响

The influence of atorvastatin calcium on blood lipids,high-sensitivity C-reactive protein and atherosclerosis in patients with cerebral infarction

目的探讨阿托伐他汀钙对脑梗死患者血脂、超敏C-反应蛋白(hs-CRP)和动脉粥样硬化的影响。方法将本科2010年6月～2011年6月收治的72例脑梗死患者随机分为对照组和观察组,两组均给予基础内科治疗,而观察组在此基础上加用阿托伐他汀钙。分析两组患者治疗前、治疗6个月后的血脂情况(总胆固醇TC、甘油三脂TG、高密度脂蛋白胆固醇HDL-C和低密度脂蛋白胆固醇LDL-C)、血浆hs-CRP、颈动脉中层内膜厚度IMT及动脉粥样硬化斑块指标(直径、厚度、面积、积分及疗效)。结果两组治疗前的指标均无统计学差异,但观察组治疗后的TC(P<0.01)、TG(P<0.05)、LDL-C(P<0.05)、hs-CRP(P<0.05)、IMT(P<0.05)和斑块指标均低于对照组,且斑块治疗总有效率高于对照组(94.44%vs.75.00%,P<0.05),显效例数多于对照组(P<0.05)。结论阿托伐他汀钙可改善脑梗死患者的血脂及hs-CRP水平,并降低斑块指标且提高斑块治疗有效率,可在脑梗死的临床治疗中进行推广。

Objective To explore the influence of atorvastatin calcium on blood lipids,high-sensitivity C-reactive protein and atherosclerosis in patients with cerebral infarction.Methods 72 patients with cerebral infarction admitted by our hospital from June 2010 to June 2011 were randomly divided into Control group and Observation group.Both groups received basic medical treatment,while only the Observation group was given atorvastatin calcium additionally.The lipid（TC,TG,HDL-C and LDL-C）,plasma hs-CRP level and atherosclerotic plaque indicators（diameter,thickness,area,integral and efficacy） before treatment and 6th month after treatment were investigated.Results The levels of TC（P0.01）,TG（P0.05）,LDL-C（P0.05）,hs-CRP（P0.05）,IMT（P0.05） and plaque indicators of Observation group were lower than the Control group.The efficiency of plaques treatment in Observation group was higher than that in control group（P0.05）.Conclusion Atorvastatin calcium can improve blood lipids and hs-CRP levels of patients with cerebral infarction,reduce plaque indicators and elevate the efficiency of plaque treatment.