全麻诱导中芬太尼用量对帕瑞昔布钠术后镇痛效果的影响

Fentanyl dosage during induction of general anesthesia on Parry coxib sodium postoperative analgesia effect

目的观察短小手术全麻诱导中芬太尼用量对帕瑞昔布钠术后镇痛效果的影响。方法选择行电视腹腔镜胆囊摘除手术(LC)患者120例,随机分为较小剂量芬太尼(1.0～2μg/kg)全麻诱导组(Ⅰ组)及较大剂量(2.5～4.0μg/kg)芬太尼诱导组(Ⅱ组)。所有患者均采用气管内插管全凭静脉复合麻醉。两组术中均用丙泊酚6.0～8.0mg/(kg.h)、雷米芬太尼0.12～0.2μg/(kg.min)维持麻醉深度。手术缝皮时两组均推注帕瑞昔布钠40mg。记录术后2、4、6、12、24h各时点VAS疼痛评分,对两组各时点VAS评分进行统计分析。结果Ⅰ组VAS评分在2、4、6h时点高于N组(P<0.05),在12、24h时点略高于Ⅱ组,但无显著差异(P>0.05)。结论全麻诱导中,芬太尼用量不足能影响到帕瑞昔布钠的术后镇痛效果。

Objective To observe the short operation during induction of general anesthesia with fentanyl dosage on Parry coxib sodium postoperative analgesia effect.Methods Choose laparoscopic cholecystectomy operation（LC） in 120 patients,randomly divided into smaller doses of fentanyl（1.0~2μg/kg） during induction of general anesthesia group（group Ⅰ） and a larger dose（2.5~4.0μg/kg）induced by fentanyl group（group Ⅱ）.All patients were treated with endotracheal intubation for total intravenous anesthesia.Two groups in both the use of remifentanil propofol 6.0~8.0mg/（kg·h）,0.12~0.2μg/（kg·min） maintenance of anesthesia depth.Operation skin suture in two groups were injected parecoxib sodium 40mg.Recorded after 2、4、6、12、24h VAS pain score of each point,each of the two groups at VAS score for statistical analysis.Results In group ⅠVAS score at 2、4、6h times higher than that in N group（P0.05）,in 12,at 24h is slightly higher than that of group II,but no significant difference（P0.05）.Conclusion During induction of general anesthesia with fentanyl dosage,can affect parecoxib in postoperative analgesia.