剩余风险——后低密度脂蛋白胆固醇时代到来?

Residual Risk——The Era of Post Low-density Lipoprotein Cholesterol?

目前认为虽经过积极控制心血管疾病的危险因素,仍未能完全控制心血管疾病的发生发展,其主要原因在于心血管疾病"剩余风险"。血脂剩余风险主要包括三酰甘油升高,高密度脂蛋白胆固醇降低,或同时伴有载脂蛋白B和微小低密度脂蛋白升高;非脂类因素中,尿酸、高同型半胱氨酸血症及高纤维蛋白原血症等也在动脉粥样硬化等血管事件中起推动作用。此外、C反应蛋白、代谢综合征、激素、感染、内脂素等也通过不同途径影响冠心病的发生发展。

Although people were working hard to control the risk factors of cardiovascular disease,the occurrence and development of cardiovascular disease yet not able to be fully controlled.The main reason is the ＂residual risks＂of cardiovascular disease.Residual risks including the increasing of triglycerides,high-density lipoprotein cholesterol,or apolipoprotein B in blood,sometimes accompanied by a slight increase in low-density lipoprotein.Non-lipid factors,such as uric acid,homocysteine and hyperfibrinogenemia are also other vascular events in the cardiovascular dieases.In addition,C-reactive protein,metabolic syndrome,hormones,infection and visfatin may affect the development of coronary heart disease through different channels.