药物洗脱支架术后晚期和晚晚期支架内血栓的发生机制

Mechanism of Late and Very Late In-stent Thrombosis after Drug-eluting Stent Implantation

药物洗脱支架时代,支架内再狭窄的发生率已经被显著降低,相反,由于内膜延迟愈合导致的晚期和晚晚期支架内血栓使患者的心肌梗死发生率和病死率较高,逐渐引起人们的重视和关注,但其发生的具体机制尚不明确,现详细阐述药物洗脱支架术后晚期支架内血栓发生的现状,并针对晚期支架内血栓发生的可能机制进行深入的探讨。

In the time of drug-eluting stents,the incidence of in-stent restenosis has been significantly reduced.On the contrary,because of delayed endothelial healing,the patients complicated with late and very late in-stent thrombosis have higher mortality and incidence of acute myocardial infarction,which gradually attracts our attention.However,the exact mechanism is still not clear.This paper will expound the current situation and possible mechanisms of the late in-stent thrombosis occurred after drug-eluting stent implantation.