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干细胞与生物起搏 被引量：3

Creating a Biological Pacemaker Using Stem Cells
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摘要 目前临床治疗严重心动过缓的主要措施是植入电子起搏器,越发追求多元化、自动化、生理化,但是存在很多局限性,如电池寿命有限、心脏永久性植入导管、不受神经体液因素调节等。于是构建一种"生物起搏器"应运而生。干细胞移植心脏生物起搏即诱导干细胞分化成具有起搏和传导功能的细胞,重建心脏的起搏和传导功能,对受损的自律性节律点或特殊传导系统的细胞进行修复或替代,弥补窦房结或房室结功能不足,改善病人生存状况,干细胞与心脏生物起搏已经成为研究热点。 The primary treatment for severe bradycardia is a pacemaker.However,the pacemaker has many limitations.These limitations are leading researchers to search for a biological pacemaker.Stem cells are being considered for the formation of this biological pacemaker.The stem cells would be transplanted in order to reconstruct the heart’s sinus SA node or the atrioventricular node.
作者 郭晓华 张宇
机构地区 新疆医科大学第一附属医院起搏电生理科
出处 《心血管病学进展》 CAS 2013年第4期568-571,共4页 Advances in Cardiovascular Diseases
关键词 干细胞 移植 心律失常 心脏生物起搏 stem cell transplantation arrhythmias cardiac biological pacemaker
分类号 R541.7 [医药卫生—心血管疾病]
  • 相关文献

参考文献21

  • 1李北方,刘仁光,朱明星.干细胞移植与心脏生物起搏的研究现状[J].中国组织工程研究与临床康复,2009,13(36):7151-7154. 被引量：3
  • 2Plotnikov AN, Shlapakova I, Szabolcs M J, et al. Xenografted adult human meseu- chymal stem cells provide a platform for sustained biological pacemaker function in canine heart[J]. Circulation,2007,116(7) :706-713.
  • 3Heubach JF, Graf EM, Leutheuser J, et al. Electrophysiological properties of human mesenchymal stem cells[J]. J Physiol,2004,554(pt 3) :659-672.
  • 4Potapova I, Plontnikov A, Lu Z, et al. Human mesenchymal stem cells as a gene delivery system to create cardiac pacemakers [ J ]. Circ Res, 2004,94 (7) : 952-959.
  • 5姚颖龙,张浩,龚德军,宋智刚,徐志云.超极化激活环化核苷酸门控通道基因转染猪骨髓间充质干细胞[J].中国组织工程研究与临床康复,2009,13(49):9673-9676. 被引量：5
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二级参考文献47

  • 1任晓庆,浦介麟,张澍,贾玉和,赵欣然,孟亮,王方正.自体骨髓间叶干细胞诱导分化移植重建窦房结起搏功能的实验研究[J].中国循环杂志,2004,19(6):462-465. 被引量：15
  • 2徐兆龙,刘仁光.心脏生物起搏的研究进展[J].国际心血管病杂志,2007,34(2):83-85. 被引量：3
  • 3Gepstein L,Feld Y,Yankelson L.Someatic and cell therapy strategies for the treatment of cardiac arrhythmias[J].Am J Physi Heart Circ Physiol.2004,286(3): H815-822.
  • 4Kehat I,Gepstein A,Spira A,et al.High-reaolution electrophysiological assessment of human embryonic stem cell-derived cardiomyocytes: a novel in vitro model for the study of conduction. [J].Circ Res. 2002 ,91(8):659-661.
  • 5Kehat I,Khimovich L,Caspi O,etal.Electromechanical integration of cardiomyocytes derived from human embryonic stem cells[J].Nat Biotechnol,2004,22(10):1282-1289.
  • 6Xue T, Cho HC, Akar FG, et al.Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes:insights into the development of cell-based pacemakers[J]. Circulation,2005,111(1):11-20.
  • 7Ou DB,Lang HJ,Chen R,et al.Using embryonic stem cells to form a biological pacemaker via tissue engineering technology[J]. Bioessays, 2009,31(2):246-252.
  • 8Plotnikov AN,Shlapakova I,Szabolcs MJ,et al.Xenografted adult human mesenchymal stem cells provide a platform for sustained biological pacemaker function in canine heart[J].Circulation. 2007,116(7):706-713.
  • 9Heubach JF,Graf EM,Leutheuser J,et al.Electrophysiological properties of human mesenchymal stem cells[J].J Physiol,2004,554(Pt3):659-672.
  • 10Zhang YM,Hartzell C,Narlow M,et al.Stem cell derived cardiomyocytes demonstrate arrhythmic potential[J].Circulation,2002,106(10):1294-1299.

共引文献6

同被引文献18

引证文献3

二级引证文献12

心血管病学进展
2013年 第4期

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