序贯机械通气治疗AECOPD合并肺性脑病的疗效观察

Observation of efficacy of sequential mechanical ventilation in the treatment of AECOPD patients complicated with pulmonary encephalopathy

目的探讨序贯机械通气治疗慢性阻塞性肺疾病急性加重期(AECOPD)合并肺性脑病患者中的疗效。方法对我院收治的64例AECOPD患者,将其按入院随机号分为两组,每组各32例,对照组患者给予有创机械通气,观察组给予有创-无创序贯机械通气,比较两组患者的临床治疗疗效。结果观察组患者总有效率为90.63%,对照组总有效率为71.88%,差异具有显著的统计学意义(P<0.05);观察组患者有创通气时间、总机械通气时间、住RICU时间均明显短于对照组,且插管再通率、VAP发生率均显著低于对照组;住院费用明显少于对照组,(P<0.05)。结论有创-无创序贯机械通气治疗AECOPD合并肺性脑病,能显著缩短通气时间,降低VAP发生率。

Objective To investigate the curative effect of sequential mechanical ventilation in the treatment of AECOPD patients complicated with pulmonary encephalopathy. Methods 64 AECOPD patients were randomly and evenly divided into two groups. The control group was treated with invasive mechanical ventilation, and the observation group was given invasive-non-invasive sequential me- chanical ventilation. The clinical efficacy of the two groups was compared. Results The total effective rate was 90. 63% in the observa- tion group and 71.88 % in the control group respectively, with significant difference （P 〈 0. 05 ）. The duration of invasive ventilation, to- tal mechanical ventilation, and RICU stay was significantly shorter in the observation group than in the control group, and the rate of intu- bation recanalization, the incidence of VAP and hospitalization cost were significantly less in the observation group than in the control group （ P 〈 0.05）. Conclusion Invasive non-invasive sequential mechanical ventilation can significantly shorten the duration of ventila- tion, reduce the incidence of VAP, and improve their quality of life in the treatment of AECOPD patients complicated with pulmonary en- cephalopathy.