相邻三县区妇女感染人乳头瘤病毒分子流行病学分析

Molecular epidemiological analysis of human papillomavirus in women from three adjacent counties

目的研究相邻三县区(沾化县、利津县及河口区)妇女宫颈感染人乳头瘤病毒(HPV)的状况,分析HPV亚型的分布情况,为防治宫颈癌提供依据。方法2011年1月至2013年4月,采用核酸分子快速导流杂交技术,对三县区的6118例妇女进行宫颈分泌物21种HPV亚型的筛查。结果6118例妇女宫颈感染HPV筛查阳性率为29.3%(1790/6118),青年妇女感染HPV的阳性率(33.7%)显著高于中年妇女(19.4%)及老年妇女(16.3%)(P<0.01),中年妇女与老年妇女差异无显著性(P>0.05)。多重感染HPV亚型者(67.3%)显著高于单一亚型(32.7%)(P<0.01),以二重亚型及三重亚型感染为主(发生率为59.0%)。高危型HPV亚型的检出率为72.1%(2668/3698),主要为HPV16(27.0%)、HPV18(15.4%)、HPV58(13.1%)、HPV31(6.1%)及HPV52(5.7%)。结论三县区妇女宫颈HPV的感染率、多重感染率及高危型HPV感染率均较高,高危型HPV以HPV16、18、58、31及52亚型为主。

Objective To research the human papillomavirus （HPV） infection in women from three adjacent counties, analyze the distribution of HPV subtypes, and provide a basis for cervical cancer prevention and treatment. Methods From January 2011 to April 2013, to screen the 21 kinds of HPV subtypes in cervical secretion samples of 6118 women from the three counties, flow- through hybridization technology was used. Results Among the 6118 women, the HPV infection rate was 29.3% （1790/6118）. The positive rate in young women group （33.7%） was significantly higher than that in middle-aged women group （19.4%） （P〈0.01）. The positive rate in middle-aged women group was nearly the same as that in older women group （16.3%） （/9〉0.05）. The rate of multi- ple infection of HPV subtypes （67.3%） which mainly including double subtypes and triple subtypes infection （59.0%） was signifi- cantly higher than the single subtype infection （32.7%）（P〈0.01）. The high-risk HPV subtype ratio was 72.1% （2668/3698）, includ- ing HPV16 （27.0%）, HPV18 （15.4%）, HPV58 （13.1%）, HPV31 （6.1%） and HPV52 （5.7%）. Conclusion The infection rate（single or multiple infection or high-risk subtype infection） of HPV is quite high in the three adjacent counties＂ women.