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尿Netrin-1与NGAL联合检测在成人体外循环术后急性肾损伤早期诊断中的意义 被引量：5

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摘要 目的探讨尿神经导向因子-1(Netrin-1)及中性粒细胞明胶酶相关脂质运载蛋白(NGAL)联合检测在体外循环(car-diopulmonary bypass,CPB)术后急性肾损伤(acute kidney injury,AKI)早期诊断中的价值与意义。方法选择213例在CPB下行心脏手术的成人心脏病患者,CPB结束后第一个12 h内每2 h采集尿样及血样1次,此后72h内每12 h采集1次,对尿中Netrin-1、NGAL进行定量分析,同时检测相应时间点血清肌酐(Scr)水平,Scr比正常基础水平升高50%以上为发生AKI的标准。结果术后3d内有40例患者发生不同程度AKI,发生率18.8%,AKI组Scr在CPB术后24 h才开始上升,而尿Netrin-1及NAGL在术后2h均显著升高,术后2hROC曲线下面积分别为0.906、0.901,两者联合检测ROC曲线下面积则为0.958。结论尿Netrin-1和NAGL可以作为早期诊断CPB术后AKI的敏感性和特异性较高的生物学标志物,两者联合检测可提高A-KI早期诊断的效果。
作者 陈玉 王艳琴 蔡利励 郑剑锋 王小中
机构地区 南昌大学第二附属医院检验科 南昌市第二医院检验科
出处 《实验与检验医学》 CAS 2013年第4期328-330,共3页 Experimental and Laboratory Medicine
关键词 肾损伤 急性 体外循环 神经导向因子 中性粒细胞明胶酶相关脂质运载蛋白 早期诊断
分类号 R446.112 [医药卫生—诊断学] R446.62 [医药卫生—诊断学]
  • 相关文献

参考文献9

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二级参考文献38

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共引文献27

同被引文献53

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引证文献5

二级引证文献18

实验与检验医学
2013年 第4期

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